Heightened cortisol response to administration of naloxone in tourette's syndrome

Reuven Sandyk; Colin R. Bamford

doi:10.3109/00207458808985707

Heightened cortisol response to administration of naloxone in tourette's syndrome

Reuven Sandyk, Colin R. Bamford

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The release of corticotrophin-releasing factor (CRF) in the human has been shown to be under a direct inhibitory control derived from the locus coeruleus (LC). Opioids have been shown to inhibit CRF release. Based on our hypothesis of deranged opioid-noradrenergic activity in Tourette's syndrome (TS), we studied the effect of a naloxone challenge on plasma cortisol levels in 6 TS patients. In all patients naloxone produced a significant rise in cortisol secretion. These results support our hypothesis and suggest that in TS, noradrenergic LC receptors involved in CRF release are supersensitive as a result of chronic excessive endorphinergic activity.

Original language	English (US)
Pages (from-to)	225-227
Number of pages	3
Journal	International Journal of Neuroscience
Volume	39
Issue number	3-4
DOIs	https://doi.org/10.3109/00207458808985707
State	Published - 1988

Keywords

CRF
Cortisol
Locus coeruleus
Naloxone
Noradrenaline
Opioids
Tourette's syndrome

ASJC Scopus subject areas

Neuroscience(all)

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10.3109/00207458808985707

Cite this

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title = "Heightened cortisol response to administration of naloxone in tourette's syndrome",

abstract = "The release of corticotrophin-releasing factor (CRF) in the human has been shown to be under a direct inhibitory control derived from the locus coeruleus (LC). Opioids have been shown to inhibit CRF release. Based on our hypothesis of deranged opioid-noradrenergic activity in Tourette's syndrome (TS), we studied the effect of a naloxone challenge on plasma cortisol levels in 6 TS patients. In all patients naloxone produced a significant rise in cortisol secretion. These results support our hypothesis and suggest that in TS, noradrenergic LC receptors involved in CRF release are supersensitive as a result of chronic excessive endorphinergic activity.",

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AU - Bamford, Colin R.

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AB - The release of corticotrophin-releasing factor (CRF) in the human has been shown to be under a direct inhibitory control derived from the locus coeruleus (LC). Opioids have been shown to inhibit CRF release. Based on our hypothesis of deranged opioid-noradrenergic activity in Tourette's syndrome (TS), we studied the effect of a naloxone challenge on plasma cortisol levels in 6 TS patients. In all patients naloxone produced a significant rise in cortisol secretion. These results support our hypothesis and suggest that in TS, noradrenergic LC receptors involved in CRF release are supersensitive as a result of chronic excessive endorphinergic activity.

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KW - Locus coeruleus

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KW - Noradrenaline

KW - Opioids

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Heightened cortisol response to administration of naloxone in tourette's syndrome

Abstract

Keywords

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