Hedgehog signalling in gut development, physiology and cancer

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

The Hedgehog pathway is one of the most common signal transduction pathways used by mammalian cells. Most studies have focused on its role during development, primarily of the nervous system, skin, bone and pancreas. Due to the activation of this pathway during proliferation and neoplastic transformation, more recent studies have examined its role in adult tissues. Significant levels of sonic hedgehog are expressed in the gastric mucosa, which has served to direct analysis of its role during organogenesis, gastric acid secretion and neoplastic transformation. Therefore the goal of this review is to apply current knowledge of this pathway to further our understanding of gastrointestinal physiology and neoplasia, using the stomach as a prototype.

Original languageEnglish (US)
Pages (from-to)421-432
Number of pages12
JournalJournal of Physiology
Volume590
Issue number3
DOIs
StatePublished - Feb 2012
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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