TY - JOUR
T1 - Hedgehog signalling in gut development, physiology and cancer
AU - Merchant, Juanita L.
PY - 2012/2
Y1 - 2012/2
N2 - The Hedgehog pathway is one of the most common signal transduction pathways used by mammalian cells. Most studies have focused on its role during development, primarily of the nervous system, skin, bone and pancreas. Due to the activation of this pathway during proliferation and neoplastic transformation, more recent studies have examined its role in adult tissues. Significant levels of sonic hedgehog are expressed in the gastric mucosa, which has served to direct analysis of its role during organogenesis, gastric acid secretion and neoplastic transformation. Therefore the goal of this review is to apply current knowledge of this pathway to further our understanding of gastrointestinal physiology and neoplasia, using the stomach as a prototype.
AB - The Hedgehog pathway is one of the most common signal transduction pathways used by mammalian cells. Most studies have focused on its role during development, primarily of the nervous system, skin, bone and pancreas. Due to the activation of this pathway during proliferation and neoplastic transformation, more recent studies have examined its role in adult tissues. Significant levels of sonic hedgehog are expressed in the gastric mucosa, which has served to direct analysis of its role during organogenesis, gastric acid secretion and neoplastic transformation. Therefore the goal of this review is to apply current knowledge of this pathway to further our understanding of gastrointestinal physiology and neoplasia, using the stomach as a prototype.
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U2 - 10.1113/jphysiol.2011.220681
DO - 10.1113/jphysiol.2011.220681
M3 - Review article
C2 - 22144577
AN - SCOPUS:84856314865
SN - 0022-3751
VL - 590
SP - 421
EP - 432
JO - Journal of Physiology
JF - Journal of Physiology
IS - 3
ER -