TY - JOUR
T1 - Hedgehog signaling in the stomach
AU - Konstantinou, Daniel
AU - Bertaux-Skeirik, Nina
AU - Zavros, Yana
N1 - Funding Information:
This work was supported by NIH 2 R01 DK083402-06 grant and The University of Cincinnati , College of Medicine Bridge Funding Program (Y. Zavros). Albert J. Ryan Fellowship, Dean's Fellowship , NIH5T32GM105526 grant (N. Bertaux-Skeirik).
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The Hedgehog (Hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. In particular, Sonic Hedgehog (Shh) signaling has been well studied for its role in gastric physiology and pathophysiology. Shh is secreted from the gastric parietal cells and contributes to the regeneration of the epithelium in response to injury, or the development of gastritis during Helicobacter pylori infection. Dysregulation of the Shh signaling pathway leads to the disruption of gastric differentiation, loss of gastric acid secretion and the development of cancer. In this chapter, we will review the most recent findings that reveal the role of Shh as a regulator of gastric physiology, regeneration, and disease.
AB - The Hedgehog (Hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. In particular, Sonic Hedgehog (Shh) signaling has been well studied for its role in gastric physiology and pathophysiology. Shh is secreted from the gastric parietal cells and contributes to the regeneration of the epithelium in response to injury, or the development of gastritis during Helicobacter pylori infection. Dysregulation of the Shh signaling pathway leads to the disruption of gastric differentiation, loss of gastric acid secretion and the development of cancer. In this chapter, we will review the most recent findings that reveal the role of Shh as a regulator of gastric physiology, regeneration, and disease.
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U2 - 10.1016/j.coph.2016.09.003
DO - 10.1016/j.coph.2016.09.003
M3 - Review article
C2 - 27750091
AN - SCOPUS:84991769853
SN - 1471-4892
VL - 31
SP - 76
EP - 82
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
ER -