Hedgehog signaling in the stomach

Daniel Konstantinou, Nina Bertaux-Skeirik, Yana Zavros

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

The Hedgehog (Hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. In particular, Sonic Hedgehog (Shh) signaling has been well studied for its role in gastric physiology and pathophysiology. Shh is secreted from the gastric parietal cells and contributes to the regeneration of the epithelium in response to injury, or the development of gastritis during Helicobacter pylori infection. Dysregulation of the Shh signaling pathway leads to the disruption of gastric differentiation, loss of gastric acid secretion and the development of cancer. In this chapter, we will review the most recent findings that reveal the role of Shh as a regulator of gastric physiology, regeneration, and disease.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume31
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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