Healing of Chronic Wounds: An Update of Recent Developments and Future Possibilities

Mustafa Hussain Kathawala, Wei Long Ng, Dan Liu, May Win Naing, Wai Yee Yeong, Kara L. Spiller, Mark Van Dyke, Kee Woei Ng

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Chronic wounds are the result of disruptions in the body's usual process of healing. They are not only a source of significant pain and discomfort but also, more importantly, an unguarded port of entry for pathogens into the body. While our current understanding of this phenomenon is far from complete, findings in physiological patterns and advancements in wound healing technologies have helped develop wound management and healing solutions to this long-standing medical challenge. This review presents an overview of known wound healing mechanics, abnormalities that lead to chronic wounds, and a summary of established and new wound healing technologies. Various approaches to heal wounds are discussed, from dermal replacements to advanced biomaterial-based treatments, from cell-, synthetic-, and composite-based approaches to preclinical approaches, which make developing such products possible. While tested breakthrough products are described, the authors focused more on recently developed innovations, which are at varying stages of maturity. The review concludes with a note on future perspectives and opinions on where the field and industry are headed and where they should be.

Original languageEnglish (US)
Pages (from-to)429-444
Number of pages16
JournalTissue Engineering - Part B: Reviews
Volume25
Issue number5
DOIs
StatePublished - Oct 2019
Externally publishedYes

Keywords

  • biologics
  • biomaterials
  • chronic wounds
  • dressings
  • scaffolds
  • skin bioprinting

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

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