Halicylindramides A-C, Antifungal and Cytotoxic Depsipeptides from the Marine Sponge Halichondria cylindrata

Hong yu Li; Shigeki Matsunaga; Nobuhiro Fusetani

doi:10.1021/jm00002a015

Halicylindramides A-C, Antifungal and Cytotoxic Depsipeptides from the Marine Sponge Halichondria cylindrata

Hong yu Li, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Halicylindramides A-C (1–3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.

Original language	English (US)
Pages (from-to)	338-343
Number of pages	6
Journal	Journal of Medicinal Chemistry
Volume	38
Issue number	2
DOIs	https://doi.org/10.1021/jm00002a015
State	Published - Jan 1 1995
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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author = "Li, {Hong yu} and Shigeki Matsunaga and Nobuhiro Fusetani",

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AU - Li, Hong yu

AU - Matsunaga, Shigeki

AU - Fusetani, Nobuhiro

PY - 1995/1/1

Y1 - 1995/1/1

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AB - Halicylindramides A-C (1–3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.

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Halicylindramides A-C, Antifungal and Cytotoxic Depsipeptides from the Marine Sponge Halichondria cylindrata

Abstract

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