H-2 effects on cell-cell interactions in the response to single NON-H-2 alloantigens: I. Donor H-2D region control of H-7.1-immunogenicity and lack of Restriction In Vivo*

Genes in the H-2 complex regulate the relative immunogenicity of the H-7.1 histocompatibility alloantigen, as measured by survival times of H-7.1-incompatible skin grafts in vivo. The gene controlling relative rejectability of H-7.1- incompatible grafts has been mapped to the H-2D region. H-7.1-incompatible skin grafts donated by H-2D b donors were rejected significantly more rapidly by H-2^a/H-2^b heterozygous recipients than similar H-7.1-incompatible grafts donated by H-2D^d donors. Further, there was absolutely no evidence of H-2 restriction in cytotoxic effector activity. In vivo cross-priming, as indicated by accelerated secondary graft rejection, was extensive. The efficiency of crosspriming was dependent upon the primary and secondary graft donor H-2 haplotypes.