Gradient- and Sensitivity-Enhanced TOCSY Experiments

Katalin E. Kövér; Dušan Uhrín; Victor J. Hruby

doi:10.1006/jmre.1997.1309

Gradient- and Sensitivity-Enhanced TOCSY Experiments

Katalin E. Kövér, Dušan Uhrín, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

A pulsed field gradient version of the sensitivity-enhanced 2D TOCSY experiment is proposed which yields high-quality spectra with improved sensitivity and a minimum of two scans per t₁ increment. For rapid acquisition of ID TOCSY spectra, the 1D DPFGSE-TOCSY experiment was modified to include phase-encoded multiple-selective excitation followed by a simple spectral editing. Combination of these two building blocks is used in a sensitivity-enhanced 2D analog of the 3D TOCSY-TOCSY experiment which provides an efficient tool for resolving severely overlapped signals of oligomers in short experimental time.

Original language	English (US)
Pages (from-to)	162-168
Number of pages	7
Journal	Journal of Magnetic Resonance
Volume	130
Issue number	2
DOIs	https://doi.org/10.1006/jmre.1997.1309
State	Published - Feb 1998
Externally published	Yes

Keywords

1D DPFGSE-TOCSY
2D analog of 3D TOCSY-TOCSY
Echo-antiecho selection
Gradient version of 2D TOCSY
Multiple-selective excitation
Sensitivity enhancement

ASJC Scopus subject areas

Biophysics
Biochemistry
Nuclear and High Energy Physics
Condensed Matter Physics

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10.1006/jmre.1997.1309

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title = "Gradient- and Sensitivity-Enhanced TOCSY Experiments",

abstract = "A pulsed field gradient version of the sensitivity-enhanced 2D TOCSY experiment is proposed which yields high-quality spectra with improved sensitivity and a minimum of two scans per t1 increment. For rapid acquisition of ID TOCSY spectra, the 1D DPFGSE-TOCSY experiment was modified to include phase-encoded multiple-selective excitation followed by a simple spectral editing. Combination of these two building blocks is used in a sensitivity-enhanced 2D analog of the 3D TOCSY-TOCSY experiment which provides an efficient tool for resolving severely overlapped signals of oligomers in short experimental time.",

keywords = "1D DPFGSE-TOCSY, 2D analog of 3D TOCSY-TOCSY, Echo-antiecho selection, Gradient version of 2D TOCSY, Multiple-selective excitation, Sensitivity enhancement",

author = "K{\"o}v{\'e}r, {Katalin E.} and Du{\v s}an Uhr{\'i}n and Hruby, {Victor J.}",

note = "Funding Information: K.E.K. thanks the National Research Foundation (OTKA T 014982 and OTKA D 23749) and Ministry of Education (FKFP 0500/1997) for financial support. The purchase of the spectrometer used in the study was supported by OMFB Mec-93-0098, Phare-Accord H-9112-0198, and OTKA A084. This work was, in part (D.U.), supported by the Wellcome Trust. The support from NIDA Grant DA 06284 and USPHS Grant DKI7420 is also acknowledged by V.J.H. We thank Dr. J. Hirsch for the sample of the trisaccharide, S. Liao for the deltorphin analog, and Dr. A. Soteriou for reading the manuscript.",

year = "1998",

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doi = "10.1006/jmre.1997.1309",

language = "English (US)",

volume = "130",

pages = "162--168",

journal = "Journal of Magnetic Resonance",

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publisher = "Academic Press Inc.",

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AU - Kövér, Katalin E.

AU - Uhrín, Dušan

AU - Hruby, Victor J.

N1 - Funding Information: K.E.K. thanks the National Research Foundation (OTKA T 014982 and OTKA D 23749) and Ministry of Education (FKFP 0500/1997) for financial support. The purchase of the spectrometer used in the study was supported by OMFB Mec-93-0098, Phare-Accord H-9112-0198, and OTKA A084. This work was, in part (D.U.), supported by the Wellcome Trust. The support from NIDA Grant DA 06284 and USPHS Grant DKI7420 is also acknowledged by V.J.H. We thank Dr. J. Hirsch for the sample of the trisaccharide, S. Liao for the deltorphin analog, and Dr. A. Soteriou for reading the manuscript.

PY - 1998/2

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AB - A pulsed field gradient version of the sensitivity-enhanced 2D TOCSY experiment is proposed which yields high-quality spectra with improved sensitivity and a minimum of two scans per t1 increment. For rapid acquisition of ID TOCSY spectra, the 1D DPFGSE-TOCSY experiment was modified to include phase-encoded multiple-selective excitation followed by a simple spectral editing. Combination of these two building blocks is used in a sensitivity-enhanced 2D analog of the 3D TOCSY-TOCSY experiment which provides an efficient tool for resolving severely overlapped signals of oligomers in short experimental time.

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KW - 2D analog of 3D TOCSY-TOCSY

KW - Echo-antiecho selection

KW - Gradient version of 2D TOCSY

KW - Multiple-selective excitation

KW - Sensitivity enhancement

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Gradient- and Sensitivity-Enhanced TOCSY Experiments

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Keywords

ASJC Scopus subject areas

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