Gonyauline: A novel endogenous substance shortening the period of the circadian clock of a unicellular alga

T. Roenneberg; H. Nakamura; L. D. Cranmer; K. Ryan; Y. Kishi; J. W. Hastings

doi:10.1007/BF02041268

Gonyauline: A novel endogenous substance shortening the period of the circadian clock of a unicellular alga

T. Roenneberg, H. Nakamura, L. D. Cranmer, K. Ryan, Y. Kishi, J. W. Hastings

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The circadian clock in the unicellular alga Gonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.

Original language	English (US)
Pages (from-to)	103-106
Number of pages	4
Journal	Experientia
Volume	47
Issue number	1
DOIs	https://doi.org/10.1007/BF02041268
State	Published - Jan 1991
Externally published	Yes

Keywords

Circadian rhythm
Gonyaulax polyedra
S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid
creatine
period length

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/BF02041268

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abstract = "The circadian clock in the unicellular alga Gonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.",

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year = "1991",

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AU - Nakamura, H.

AU - Cranmer, L. D.

AU - Ryan, K.

AU - Kishi, Y.

AU - Hastings, J. W.

PY - 1991/1

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AB - The circadian clock in the unicellular alga Gonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.

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KW - Gonyaulax polyedra

KW - S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid

KW - creatine

KW - period length

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Gonyauline: A novel endogenous substance shortening the period of the circadian clock of a unicellular alga

Abstract

Keywords

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