Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat

Sun Cheung; Ronald P. Hammer

doi:10.1016/S0304-3940(97)00173-0

Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat

Sun Cheung, Ronald P. Hammer

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.

Original language	English (US)
Pages (from-to)	181-184
Number of pages	4
Journal	Neuroscience Letters
Volume	224
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(97)00173-0
State	Published - 1997
Externally published	Yes

Keywords

Arcuate nucleus
Estrogen
Hypothalamus
Median eminence
Opioid
Progesterone
Proopiomelanocortin
β-Endorphin

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(97)00173-0

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title = "Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat",

abstract = "The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.",

keywords = "Arcuate nucleus, Estrogen, Hypothalamus, Median eminence, Opioid, Progesterone, Proopiomelanocortin, β-Endorphin",

author = "Sun Cheung and Hammer, {Ronald P.}",

note = "Funding Information: This work was supported by National Science Foundation Award IBN 91-12965. The authors gratefully acknowledge continuing support of the Center for Reproductive Research at Tufts University funded by USPHS Award P30 HD28897.",

year = "1997",

doi = "10.1016/S0304-3940(97)00173-0",

language = "English (US)",

volume = "224",

pages = "181--184",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

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T1 - Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat

AU - Cheung, Sun

AU - Hammer, Ronald P.

N1 - Funding Information: This work was supported by National Science Foundation Award IBN 91-12965. The authors gratefully acknowledge continuing support of the Center for Reproductive Research at Tufts University funded by USPHS Award P30 HD28897.

PY - 1997

Y1 - 1997

N2 - The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.

AB - The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.

KW - Arcuate nucleus

KW - Estrogen

KW - Hypothalamus

KW - Median eminence

KW - Opioid

KW - Progesterone

KW - Proopiomelanocortin

KW - β-Endorphin

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DO - 10.1016/S0304-3940(97)00173-0

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AN - SCOPUS:0030890513

SN - 0304-3940

VL - 224

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat

Abstract

Keywords

ASJC Scopus subject areas

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