Gonadal Steroid Actions on Brain

S. A. Tobet, R. J. Handa

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Gonadal steroids affect many structures in the brain and other areas of the nervous system. These molecules also undergo metabolism in several brain sites, and the interactions of the resulting products influence brain development, behavior, and neuroendocrine function. Since it consists of varied regions and cell types, which exhibit a spectrum of metabolic activities, the brain can be viewed as a second endocrine system in which steroid conversions and cellular actions occur. Many expressed proteins and molecular interactions in the nervous system resemble or are the same as those of classically defined endocrine tissues that are selective for different steroids.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Number of pages7
ISBN (Print)9780080450469
StatePublished - 2009


  • Activational
  • Androgen
  • Aromatase
  • Aromatization
  • Defeminization
  • Endocrine disruptors
  • Estrogen
  • Gonadotropin-releasing hormone
  • Hypothalamus
  • Luteinizing hormone
  • Masculinization
  • Organizational
  • Phytoestrogens
  • Reductase
  • Steroid receptors

ASJC Scopus subject areas

  • General Neuroscience


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