Glycogen synthase: Key effect of exercise on insulin action

Christine Y. Christ-Roberts, Lawrence J. Mandarino

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Exercise improves insulin action in muscle, but the mechanisms are poorly characterized. Despite the notion that increased insulin signaling would accompany improved insulin sensitivity, this is not universally true. Increased activity or expression of other proteins seems to be more important. An increase in activity and expression of glycogen synthase and GLUT4 may be key to the effects of exercise.

Original languageEnglish (US)
Pages (from-to)90-94
Number of pages5
JournalExercise and Sport Sciences Reviews
Issue number3
StatePublished - Jul 2004
Externally publishedYes


  • Diabetes
  • Glucose uptake
  • Physical activity
  • Skeletal muscle

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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