@article{3db703da6da742959b8f53e8b07e595c,
title = "Glycine-based oral rehydration solution: Reassessment of safety and efficacy",
abstract = "We evaluated the safety and efficacy of a glycine-based orally administered rehydration solution by comparing it with a standard oral rehydration solution (ORS) without glycine in a randomized double-blind trial in United States infants (age<15 months) given treatment for acute gastroenteritis as inpatients or outpatients. The response to therapy (stool volume and duration of illness) was similar in the two groups, except that in four (13%) of 31 hospitalized infants receiving glycine-ORS hypernatremia developed, (one had symptoms) compared with none of 35 receiving ORS (P<0.04). Among the 77 outpatients there were no differences between the groups. This study demonstrates that glycine-ORS did not provide any therapeutic advantage over standard ORS, and hypernatremia developed in some patients receiving glycine-ORS. We suggest that caution be used with this type of solution until further safety studies have been done.",
author = "Mathuram Santosham and Burns, {Barbara A.} and Raymond Reid and Letson, {G. William} and Burris Duncan and Powlesland, {Jean A.} and Stephan Foster and Steven Garrett and Larry Croll and Wai, {Nyunt Nyunt} and Marshall, {William N.} and Janne' Almeido-Hill and Sack, {R. Bradley}",
note = "Funding Information: Orally administered rehydration solutions containing 50 to 90 mmol/L sodium and 2 gm/L glucose have been shown to be safe and efficacious for treating diarrheal dehydration in both hospitalized and ambulatory infants. ~-3 The physiologic basis for the effectiveness of ORS is the coupled transport of sodium and glucose across the intesti- The opinions in this article are those of the authors and do not necessarily reflect the views of the Indian Health Service. Supported by Contract 1 A102660 from the National Institutes of Health, National Institute of Allergy and Infectious Diseases, and by a Grant from Wyeth Laboratories. Submitted for publication March 17, 1986; accepted June 16, 1986. Reprint requests: Mathuram Santosham, M.D., Division of Geographic Medicine, Department of International Health, The Johns Hopkins University, School of Hygiene and Public Health, Rm. 5505, 615 N. Wolfe St., Baltimore, MD 21205.",
year = "1986",
month = nov,
doi = "10.1016/S0022-3476(86)80696-5",
language = "English (US)",
volume = "109",
pages = "795--801",
journal = "The Journal of Pediatrics",
issn = "0022-3476",
publisher = "Elsevier Inc.",
number = "5",
}