Abstract
We tested the hypothesis that decreased glucose transporter 1 (GLUT1) expression alters endothelial function. Nitric oxide-dependent endothelial relaxation, but not endothelium-independent relaxation, was significantly reduced in aortas from transgenic mice expressing GLUT1 antisense mRNA, compared to aortas from nontransgenic littermates. These data suggest that GLUT1-dependent glucose metabolism may play an important role in regulating endothelial function.
Original language | English (US) |
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Pages (from-to) | 213-214 |
Number of pages | 2 |
Journal | European Journal of Pharmacology |
Volume | 496 |
Issue number | 1 |
DOIs | |
State | Published - Aug 2 2004 |
Externally published | Yes |
Keywords
- Antisense
- Endothelium
- GLUT1 (glucose transporter1)
ASJC Scopus subject areas
- Pharmacology