GLUT1-deficient mice exhibit impaired endothelium-dependent vascular relaxation

James L. Park, Charles W. Heilig, Frank C. Brosius

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We tested the hypothesis that decreased glucose transporter 1 (GLUT1) expression alters endothelial function. Nitric oxide-dependent endothelial relaxation, but not endothelium-independent relaxation, was significantly reduced in aortas from transgenic mice expressing GLUT1 antisense mRNA, compared to aortas from nontransgenic littermates. These data suggest that GLUT1-dependent glucose metabolism may play an important role in regulating endothelial function.

Original languageEnglish (US)
Pages (from-to)213-214
Number of pages2
JournalEuropean Journal of Pharmacology
Volume496
Issue number1
DOIs
StatePublished - Aug 2 2004
Externally publishedYes

Keywords

  • Antisense
  • Endothelium
  • GLUT1 (glucose transporter1)

ASJC Scopus subject areas

  • Pharmacology

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