@article{ca90ad6d4c6441668e1f821d3104302d,
title = "Glucoregulatory relevance of small intestinal nutrient sensing in physiology, bariatric surgery, and pharmacology",
abstract = "Emerging evidence suggests the gastrointestinal tract plays an important glucoregulatory role. In this perspective, we first review how the intestine senses ingested nutrients, initiating crucial negative feedback mechanisms through a gut-brain neuronal axis to regulate glycemia, mainly via reduction in hepatic glucose production. We then highlight how intestinal energy sensory mechanisms are responsible for the glucose-lowering effects of bariatric surgery, specifically duodenal-jejunal bypass, and the antidiabetic agents metformin and resveratrol. A better understanding of these pathways lays the groundwork for intestinally targeted drug therapy for the treatment of diabetes.",
author = "Duca, {Frank A.} and Bauer, {Paige V.} and Hamr, {Sophie C.} and Lam, {Tony K.T.}",
note = "Funding Information: The work discussed in this review is supported by a Foundation Grant to T.K.T.L. from the Canadian Institutes of Health Research. F.A.D. is a Banting Fellow. S.C.H. is supported by a Canadian graduate scholarship from Natural Sciences and Engineering Research Council of Canada and a Banting and Best Diabetes Center graduate studentship T.K.T.L. holds the John Kitson McIvor (1915–1942) Endowed Chair in Diabetes Research and the Canada Research Chair in Obesity at the Toronto General Research Institute and the University of Toronto. The authors apologize to colleagues whose work is not referenced due to space limitation. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = sep,
day = "1",
doi = "10.1016/j.cmet.2015.07.003",
language = "English (US)",
volume = "22",
pages = "367--380",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "3",
}