Glucocorticoids regulate the concentration of glial fibrillary acidic protein throughout the brain

James P. O'Callaghan, Roberta E. Brinton, Bruce S. McEwen

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The role of glucocorticoids in the in vivo regulation of glial fibrillary acidic protein (GFAP) was examined. Corticosterone administration to adult rats resulted in decreased levels of GFAP throughout the brain whereas adrenalectomy caused levels of GFAP to increase. Corticosterone administration to adrenalectomized rats lowered GFAP levels to values below those of sham controls. Thus, the expression of GFAP throughout the brain appears to be physiologically regulated by adrenal glucocorticoids.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalBrain Research
Volume494
Issue number1
DOIs
StatePublished - Aug 7 1989
Externally publishedYes

Keywords

  • Adrenalectomy
  • Astrocyte
  • Corticosterone
  • Glial fibrillary acidic protein
  • Glucocorticoid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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