Global virulence regulation networks in phytopathogenic bacteria

Beth M. Mole, David A. Baltrus, Jeffery L. Dangl, Sarah R. Grant

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations


Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulation networks. We dissect the global regulation of four distantly related model phytopathogens to evaluate large-scale events and mechanisms that determine successful pathogenesis. Overarching themes include dependence on centralized cell-to-cell communication systems, pervasive two-component signal-transduction systems, post-transcriptional regulation systems, AraC-like regulators and sigma factors. Although these common regulatory systems control virulence, each functions in different capacities, and to differing ends, in the diverse species. Hence, the virulence regulation network of each species determines its survival and success in various life histories and niches.

Original languageEnglish (US)
Pages (from-to)363-371
Number of pages9
JournalTrends in Microbiology
Issue number8
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Virology
  • Microbiology


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