The paper presents a description of the FMD BioPortal biosurveillance system (http://fmd.ucdavis.edu/bioportal/) that is currently operating to capture, analyze, and disseminate global data on foot-and-mouth (FMD) disease. The FMD BioPortal makes available to users world-wide FMD-related data from the Institute for Animal Health at Pirbright, England. The system's tools include those for tabulating and graphing data, performing spatio-temporal cluster analysis of outbreak cases of FMD, and analyzing genomic changes in FMD viruses. The FMD BioPortal also includes the FMD News (http://fmd.ucdavis. edu/index.php?id=1), which is a near real time web search to identify and capture FMD-related news items appearing worldwide. Major systems components include a communication backbone for secure, real-time data transfer, a data analysis module that can run analytical programs to assess spatial-temporal clustering, and an interactive visualization tool for integrated analysis and display of epidemiological and genomic data.