Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

L. R. Kidd; A. Coulibaly; T. M. Templeton; W. Chen; L. O. Long; T. Mason; C. Bonilla; F. Akereyeni; V. Freeman; W. Isaacs; C. Ahaghotu; R. A. Kittles

doi:10.1038/sj.pcan.4500884

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

L. R. Kidd
, A. Coulibaly
, T. M. Templeton
, W. Chen
, L. O. Long
, T. Mason
, C. Bonilla
, F. Akereyeni
, V. Freeman
, W. Isaacs
, C. Ahaghotu
, R. A. Kittles

Surgery

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

Original language	English (US)
Pages (from-to)	284-292
Number of pages	9
Journal	Prostate Cancer and Prostatic Diseases
Volume	9
Issue number	3
DOIs	https://doi.org/10.1038/sj.pcan.4500884
State	Published - Sep 2006

Keywords

Apoptosis
Bcl-2
Prostate cancer

ASJC Scopus subject areas

Oncology
Urology
Cancer Research

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10.1038/sj.pcan.4500884

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title = "Germline BCL-2 sequence variants and inherited predisposition to prostate cancer",

abstract = "Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70\% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.",

keywords = "Apoptosis, Bcl-2, Prostate cancer",

author = "Kidd, \{L. R.\} and A. Coulibaly and Templeton, \{T. M.\} and W. Chen and Long, \{L. O.\} and T. Mason and C. Bonilla and F. Akereyeni and V. Freeman and W. Isaacs and C. Ahaghotu and Kittles, \{R. A.\}",

note = "Funding Information: We thank all the men who volunteered to participate in this genetic study. This work was supported by the NIH (1U54CA91431-01), the Department of Defense (DAMD17-00-1-0025 and DAMD 17-02-1-0067) and the Howard University Cancer Center.",

year = "2006",

month = sep,

doi = "10.1038/sj.pcan.4500884",

language = "English (US)",

volume = "9",

pages = "284--292",

journal = "Prostate Cancer and Prostatic Diseases",

issn = "1365-7852",

publisher = "Springer Nature",

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}

TY - JOUR

T1 - Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

AU - Kidd, L. R.

AU - Coulibaly, A.

AU - Templeton, T. M.

AU - Chen, W.

AU - Long, L. O.

AU - Mason, T.

AU - Bonilla, C.

AU - Akereyeni, F.

AU - Freeman, V.

AU - Isaacs, W.

AU - Ahaghotu, C.

AU - Kittles, R. A.

N1 - Funding Information: We thank all the men who volunteered to participate in this genetic study. This work was supported by the NIH (1U54CA91431-01), the Department of Defense (DAMD17-00-1-0025 and DAMD 17-02-1-0067) and the Howard University Cancer Center.

PY - 2006/9

Y1 - 2006/9

N2 - Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

AB - Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

KW - Apoptosis

KW - Bcl-2

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/33748280472

UR - https://www.scopus.com/pages/publications/33748280472#tab=citedBy

U2 - 10.1038/sj.pcan.4500884

DO - 10.1038/sj.pcan.4500884

M3 - Article

C2 - 16733517

AN - SCOPUS:33748280472

SN - 1365-7852

VL - 9

SP - 284

EP - 292

JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

IS - 3

ER -

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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