Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma

Eric Pihl; B. Jansson; M. A. Schwartz; M. A. Malahy; J. L. Smith; J. V. Gutterman; E. M. Hersh

doi:10.3109/00313028209069037

Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma

Eric Pihl, B. Jansson, M. A. Schwartz, M. A. Malahy, J. L. Smith, J. V. Gutterman, E. M. Hersh

Cancer Center

Research output: Contribution to journal › Article › peer-review

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Abstract

A quantitative immunomorphological analysis of actively responding B-(germinal centre) and T-lymphocyte (para-cortical) areas in 187 patients with malignant melanoma recurrent in the regional lymph nodes has been made. The results show that tumour involved nodes have significantly increased germinal centre and decreased paracortical response in comparison with uninvolved lymph nodes. Patients treated with surgery alone whose uninvolved nodes had hyperplastic (defined as exceeding the median) germinal centre areas, had significantly shorter survival than those without germinal centre hyperplasia. No association was found between lymph node immunomorphology and survival in BCG treated patients.

Original language	English (US)
Pages (from-to)	13-16
Number of pages	4
Journal	Pathology
Volume	14
Issue number	1
DOIs	https://doi.org/10.3109/00313028209069037
State	Published - 1982

Keywords

Germinal centres
Lymph nodes
Melanoma
Prognosis

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.3109/00313028209069037

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title = "Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma",

abstract = "A quantitative immunomorphological analysis of actively responding B-(germinal centre) and T-lymphocyte (para-cortical) areas in 187 patients with malignant melanoma recurrent in the regional lymph nodes has been made. The results show that tumour involved nodes have significantly increased germinal centre and decreased paracortical response in comparison with uninvolved lymph nodes. Patients treated with surgery alone whose uninvolved nodes had hyperplastic (defined as exceeding the median) germinal centre areas, had significantly shorter survival than those without germinal centre hyperplasia. No association was found between lymph node immunomorphology and survival in BCG treated patients.",

keywords = "Germinal centres, Lymph nodes, Melanoma, Prognosis",

author = "Eric Pihl and B. Jansson and Schwartz, {M. A.} and Malahy, {M. A.} and Smith, {J. L.} and Gutterman, {J. V.} and Hersh, {E. M.}",

note = "Funding Information: ACKNOWLEDGEMENThTiSs study was supported by Grants CA-05831 and CA-14984 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U. S .A.",

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doi = "10.3109/00313028209069037",

language = "English (US)",

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T1 - Germinal centre hyperplasia

T2 - An unfavourable immune response in recurrent malignant melanoma

AU - Pihl, Eric

AU - Jansson, B.

AU - Schwartz, M. A.

AU - Malahy, M. A.

AU - Smith, J. L.

AU - Gutterman, J. V.

AU - Hersh, E. M.

N1 - Funding Information: ACKNOWLEDGEMENThTiSs study was supported by Grants CA-05831 and CA-14984 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U. S .A.

PY - 1982

Y1 - 1982

N2 - A quantitative immunomorphological analysis of actively responding B-(germinal centre) and T-lymphocyte (para-cortical) areas in 187 patients with malignant melanoma recurrent in the regional lymph nodes has been made. The results show that tumour involved nodes have significantly increased germinal centre and decreased paracortical response in comparison with uninvolved lymph nodes. Patients treated with surgery alone whose uninvolved nodes had hyperplastic (defined as exceeding the median) germinal centre areas, had significantly shorter survival than those without germinal centre hyperplasia. No association was found between lymph node immunomorphology and survival in BCG treated patients.

AB - A quantitative immunomorphological analysis of actively responding B-(germinal centre) and T-lymphocyte (para-cortical) areas in 187 patients with malignant melanoma recurrent in the regional lymph nodes has been made. The results show that tumour involved nodes have significantly increased germinal centre and decreased paracortical response in comparison with uninvolved lymph nodes. Patients treated with surgery alone whose uninvolved nodes had hyperplastic (defined as exceeding the median) germinal centre areas, had significantly shorter survival than those without germinal centre hyperplasia. No association was found between lymph node immunomorphology and survival in BCG treated patients.

KW - Germinal centres

KW - Lymph nodes

KW - Melanoma

KW - Prognosis

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Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma

Abstract

Keywords

ASJC Scopus subject areas

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