Germ-line mutations of the macrophage scavenger receptor 1 gene: Association with prostate cancer risk in African-American men

David C. Miller, S. Lilly Zheng, Rodney L. Dunn, Aruna V. Sarma, James E. Montie, Ethan M. Lange, Deborah A. Meyers, Jianfeng Xu, Kathleen A. Cooney

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Both rare germ-line mutations and common sequence variants of the macrophage scavenger receptor 1 (MSR1) gene have recently been implicated as potential prostate cancer susceptibility factors. However, existing studies are limited by the referral-based nature of samples and a paucity of African-American participants. In this context, we evaluated the association of germ-line mutations and common MSR1 sequence variants with prostate cancer risk in a case control study of a community-based sample of 134 African-American men with prostate cancer and 340 unaffected controls. In our sample, the rare Asp174Tyr missense change was identified nearly twice as frequently in men with prostate cancer (6.8%) compared with unaffected controls (3.6%; P = 0.14). Moreover, significantly different allele frequencies between cases and controls were observed for one of the sequence variants, IVS5-59 (P = 0.02). Taken together, our results provide some additional support for the hypothesis that selected, rare MSR1 mutations are associated with increased prostate cancer susceptibility among African-American men.

Original languageEnglish (US)
Pages (from-to)3486-3489
Number of pages4
JournalCancer Research
Volume63
Issue number13
StatePublished - Jul 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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