TY - JOUR
T1 - Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees
T2 - A preliminary report
AU - Nurnberger, John I.
AU - DePaulo, J. Raymond
AU - Gershon, Elliot S.
AU - Reich, Theodore
AU - Blehar, Mary C.
AU - Edenberg, Howard J.
AU - Foroud, Tatiana
AU - Miller, Marvin
AU - Bowman, Elizabeth
AU - Mayeda, Aimee
AU - Rau, N. Leela
AU - Smiley, Carrie
AU - Conneally, P. Michael
AU - McMahon, Francis
AU - Meyers, Deborah
AU - Simpson, Sylvia
AU - McInnis, Melvin
AU - Stine, O. Colin
AU - Detera-Wadleigh, Sevilla
AU - Goldin, Lynn
AU - Guroff, Juliet
AU - Maxwell, Elizabeth
AU - Kazuba, Diane
AU - Gejman, Pablo V.
AU - Badner, Judith
AU - Sanders, Alan
AU - Rice, John
AU - Bierut, Laura
AU - Goate, Alison
PY - 1997
Y1 - 1997
N2 - Four sites collaborated with the NIMH to develop a resource for the genetic study of bipolar (BP) illness. Common methods of ascertainment and assessment were developed in 1989. A series of families with a bipolar I (BPI) proband and at least one BPI or schizo affective, bipolar type (SA/BP) first-degree relative has been studied. We now report initial data from a genomic survey with an average intermarker interval of 10 cM on 540 subjects from 97 families. This is the largest commonly ascertained and assessed linkage sample for bipolar illness reported to date; it includes 232 subjects with BPI, 32 SA/BP, 72 bipolar II (BPII), and 88 unipolar, recurrent (UPR). Nonparametric methods of analysis were employed, with all sites using affected sib pair analysis. The strongest findings thus far appear to be on chromosomes 1, 6, 7, 10, 16, and 22. Support has also been found for some previously reported linkages, including 21q and possibly Xq26. All these areas (as well as others) will be followed up with additional markers and further analyses. No locus tested thus far meets stringent criteria for an initial finding of significant linkage.
AB - Four sites collaborated with the NIMH to develop a resource for the genetic study of bipolar (BP) illness. Common methods of ascertainment and assessment were developed in 1989. A series of families with a bipolar I (BPI) proband and at least one BPI or schizo affective, bipolar type (SA/BP) first-degree relative has been studied. We now report initial data from a genomic survey with an average intermarker interval of 10 cM on 540 subjects from 97 families. This is the largest commonly ascertained and assessed linkage sample for bipolar illness reported to date; it includes 232 subjects with BPI, 32 SA/BP, 72 bipolar II (BPII), and 88 unipolar, recurrent (UPR). Nonparametric methods of analysis were employed, with all sites using affected sib pair analysis. The strongest findings thus far appear to be on chromosomes 1, 6, 7, 10, 16, and 22. Support has also been found for some previously reported linkages, including 21q and possibly Xq26. All these areas (as well as others) will be followed up with additional markers and further analyses. No locus tested thus far meets stringent criteria for an initial finding of significant linkage.
KW - Bipolar affective disorder
KW - Genetics
KW - Genomic survey
KW - Linkage
KW - Nonparametric analysis
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U2 - 10.1002/(SICI)1096-8628(19970531)74:3<227::AID-AJMG1>3.0.CO;2-N
DO - 10.1002/(SICI)1096-8628(19970531)74:3<227::AID-AJMG1>3.0.CO;2-N
M3 - Article
C2 - 9184304
AN - SCOPUS:0031004493
SN - 1552-4841
VL - 74
SP - 227
EP - 237
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 3
ER -