Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth

Medicine & Life Sciences

• Thioredoxins 100%
• Oxidation-Reduction 76%
• Melanoma 66%
• Homeostasis 58%
• Pyruvaldehyde 56%
• Glucose 50%
• Growth 40%
• 3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid 31%
• Clustered Regularly Interspaced Short Palindromic Repeats 30%
• Proteins 29%
• Neoplasms 25%
• Neoplasm Metastasis 24%
• Uridine Diphosphate N-Acetylglucosamine 21%
• Glucose-6-Phosphate 17%
• Gene Expression 15%
• SCID Mice 15%
• Gene Expression Profiling 13%
• Acceleration 12%
• Cell Division 12%
• Energy Metabolism 11%
• Glutathione 11%
• Heterografts 11%
• Prostate 11%
• Cell Cycle 10%
• Population 10%
• Carcinogenesis 10%
• Oxidative Stress 9%
• Down-Regulation 9%
• Pharmacology 8%
• Carcinoma 8%
• Phenotype 7%
• Enzymes 7%
• Genes 5%

Chemical Compounds

• Methylglyoxal 80%
• Pharmacological Metabolism 61%
• Glucose 58%
• Protein 32%
• Metabolic 32%
• Oxidative Stress 19%
• Byproduct 19%
• Metabolite 14%
• Energy 9%
• Time 7%