Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

Agnes B. Baffoe-Bonnie; Rick A. Kittles; Elizabeth Gillanders; Liang Ou; Asha George; Christiane Robbins; Chiledum Ahaghotu; James Bennett; William Boykin; Gerald Hoke; Terry Mason; Curtis Pettaway; Srinivasan Vijayakumar; Sally Weinrich; Mary P. Jones; Derek Gildea; Erica Riedesel; Julie Albertus; Tracy Moses; Erica Lockwood; Meghan Klaric; Mezbah Faruque; Charmaine Royal; Jeffrey M. Trent; Kate Berg; Francis S. Collins; Paulette M. Furbert-Harris; Joan E. Bailey-Wilson; Georgia M. Dunston; Isaac Powell; John D. Carpten

doi:10.1002/pros.20456

Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

Agnes B. Baffoe-Bonnie, Rick A. Kittles, Elizabeth Gillanders, Liang Ou, Asha George, Christiane Robbins, Chiledum Ahaghotu, James Bennett, William Boykin, Gerald Hoke, Terry Mason, Curtis Pettaway, Srinivasan Vijayakumar, Sally Weinrich, Mary P. Jones, Derek Gildea, Erica Riedesel, Julie Albertus, Tracy Moses, Erica LockwoodMeghan Klaric, Mezbah Faruque, Charmaine Royal, Jeffrey M. Trent, Kate Berg, Francis S. Collins, Paulette M. Furbert-Harris, Joan E. Bailey-Wilson, Georgia M. Dunston, Isaac Powell, John D. Carpten

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Abstract

BACKGROUND. The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of ≥4 affected. METHODS. We present a ∼10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS. Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores ≥1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families ≥2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (α = 0.33) at the Xq21 locus. Two novel peaks ≥0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS. These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.

Original language	English (US)
Pages (from-to)	22-31
Number of pages	10
Journal	Prostate
Volume	67
Issue number	1
DOIs	https://doi.org/10.1002/pros.20456
State	Published - Jan 2007

Keywords

1-LOD support interval
Aggressive disease
Genetic burden
Genetic susceptibility
HPC2/ELAC2
Metastases

ASJC Scopus subject areas

Oncology
Urology

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10.1002/pros.20456

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Baffoe-Bonnie, A. B., Kittles, R. A., Gillanders, E., Ou, L., George, A., Robbins, C., Ahaghotu, C., Bennett, J., Boykin, W., Hoke, G., Mason, T., Pettaway, C., Vijayakumar, S., Weinrich, S., Jones, M. P., Gildea, D., Riedesel, E., Albertus, J., Moses, T., ... Carpten, J. D. (2007). Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC). Prostate, 67(1), 22-31. https://doi.org/10.1002/pros.20456

Baffoe-Bonnie, AB, Kittles, RA, Gillanders, E, Ou, L, George, A, Robbins, C, Ahaghotu, C, Bennett, J, Boykin, W, Hoke, G, Mason, T, Pettaway, C, Vijayakumar, S, Weinrich, S, Jones, MP, Gildea, D, Riedesel, E, Albertus, J, Moses, T, Lockwood, E, Klaric, M, Faruque, M, Royal, C, Trent, JM, Berg, K, Collins, FS, Furbert-Harris, PM, Bailey-Wilson, JE, Dunston, GM, Powell, I & Carpten, JD 2007, 'Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)', Prostate, vol. 67, no. 1, pp. 22-31. https://doi.org/10.1002/pros.20456

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title = "Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)",

abstract = "BACKGROUND. The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of ≥4 affected. METHODS. We present a ∼10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS. Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores ≥1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families ≥2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (α = 0.33) at the Xq21 locus. Two novel peaks ≥0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS. These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.",

keywords = "1-LOD support interval, Aggressive disease, Genetic burden, Genetic susceptibility, HPC2/ELAC2, Metastases",

author = "Baffoe-Bonnie, {Agnes B.} and Kittles, {Rick A.} and Elizabeth Gillanders and Liang Ou and Asha George and Christiane Robbins and Chiledum Ahaghotu and James Bennett and William Boykin and Gerald Hoke and Terry Mason and Curtis Pettaway and Srinivasan Vijayakumar and Sally Weinrich and Jones, {Mary P.} and Derek Gildea and Erica Riedesel and Julie Albertus and Tracy Moses and Erica Lockwood and Meghan Klaric and Mezbah Faruque and Charmaine Royal and Trent, {Jeffrey M.} and Kate Berg and Collins, {Francis S.} and Furbert-Harris, {Paulette M.} and Bailey-Wilson, {Joan E.} and Dunston, {Georgia M.} and Isaac Powell and Carpten, {John D.}",

year = "2007",

month = jan,

doi = "10.1002/pros.20456",

language = "English (US)",

volume = "67",

pages = "22--31",

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T1 - Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

AU - Baffoe-Bonnie, Agnes B.

AU - Kittles, Rick A.

AU - Gillanders, Elizabeth

AU - Ou, Liang

AU - George, Asha

AU - Robbins, Christiane

AU - Ahaghotu, Chiledum

AU - Bennett, James

AU - Boykin, William

AU - Hoke, Gerald

AU - Mason, Terry

AU - Pettaway, Curtis

AU - Vijayakumar, Srinivasan

AU - Weinrich, Sally

AU - Jones, Mary P.

AU - Gildea, Derek

AU - Riedesel, Erica

AU - Albertus, Julie

AU - Moses, Tracy

AU - Lockwood, Erica

AU - Klaric, Meghan

AU - Faruque, Mezbah

AU - Royal, Charmaine

AU - Trent, Jeffrey M.

AU - Berg, Kate

AU - Collins, Francis S.

AU - Furbert-Harris, Paulette M.

AU - Bailey-Wilson, Joan E.

AU - Dunston, Georgia M.

AU - Powell, Isaac

AU - Carpten, John D.

PY - 2007/1

Y1 - 2007/1

N2 - BACKGROUND. The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of ≥4 affected. METHODS. We present a ∼10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS. Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores ≥1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families ≥2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (α = 0.33) at the Xq21 locus. Two novel peaks ≥0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS. These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.

AB - BACKGROUND. The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of ≥4 affected. METHODS. We present a ∼10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS. Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores ≥1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families ≥2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (α = 0.33) at the Xq21 locus. Two novel peaks ≥0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS. These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.

KW - 1-LOD support interval

KW - Aggressive disease

KW - Genetic burden

KW - Genetic susceptibility

KW - HPC2/ELAC2

KW - Metastases

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DO - 10.1002/pros.20456

M3 - Article

C2 - 17031815

AN - SCOPUS:33845793863

SN - 0270-4137

VL - 67

SP - 22

EP - 31

JO - Prostate

JF - Prostate

IS - 1

ER -

Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

Abstract

Keywords

ASJC Scopus subject areas

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