TY - JOUR
T1 - Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma
AU - Bouska, Alyssa
AU - McKeithan, Timothy W.
AU - Deffenbacher, Karen E.
AU - Lachel, Cynthia
AU - Wright, George W.
AU - Iqbal, Javeed
AU - Smith, Lynette M.
AU - Zhang, Weiwei
AU - Kucuk, Can
AU - Rinaldi, Andrea
AU - Bertoni, Francesco
AU - Fitzgibbon, Jude
AU - Fu, Kai
AU - Weisenburger, Dennis D.
AU - Greiner, Timothy C.
AU - Dave, Bhavana J.
AU - Gascoyne, Randy D.
AU - Rosenwald, Andreas
AU - Ott, German
AU - Campo, Elias
AU - Rimsza, Lisa M.
AU - Delabie, Jan
AU - Jaffe, Elaine S.
AU - Braziel, Rita M.
AU - Connors, Joseph M.
AU - Staudt, Louis M.
AU - Chan, Wing Chung
PY - 2014/3/13
Y1 - 2014/3/13
N2 - Follicular lymphoma (FL), the second most common type of non-Hodgkin lymphoma in the western world, is characterized by the t(14;18) translocation, which is present in up to 90% of cases. We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Common recurrent chromosomal abnormalities in FL included gains of 2, 5, 7, 6p, 8, 12, 17q, 18, 21, and X and losses on 6q and 17p. We also observed many frequent small abnormalities, including losses of 1p36.33-p36.31, 6q23.3-q24.1, and 10q23.1-q25.1 and gains of 2p16.1-p15, 8q24.13-q24.3, and 12q12-q13.13, and identified candidate genes that may be driving this selection. Recurrent abnormalities more frequent in tFL samples included gains of 3q27.3-q28 and chromosome 11 and losses of 9p21.3 and 15q. Four abnormalities, gain of X or Xp and losses of 6q23.2-24.1 or 6q13-15, predicted overall survival. Abnormalities associated with transformation of the disease likely impair immune surveillance, activate the nuclear factor-κB pathway, and deregulate p53 and B-cell transcription factors.
AB - Follicular lymphoma (FL), the second most common type of non-Hodgkin lymphoma in the western world, is characterized by the t(14;18) translocation, which is present in up to 90% of cases. We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Common recurrent chromosomal abnormalities in FL included gains of 2, 5, 7, 6p, 8, 12, 17q, 18, 21, and X and losses on 6q and 17p. We also observed many frequent small abnormalities, including losses of 1p36.33-p36.31, 6q23.3-q24.1, and 10q23.1-q25.1 and gains of 2p16.1-p15, 8q24.13-q24.3, and 12q12-q13.13, and identified candidate genes that may be driving this selection. Recurrent abnormalities more frequent in tFL samples included gains of 3q27.3-q28 and chromosome 11 and losses of 9p21.3 and 15q. Four abnormalities, gain of X or Xp and losses of 6q23.2-24.1 or 6q13-15, predicted overall survival. Abnormalities associated with transformation of the disease likely impair immune surveillance, activate the nuclear factor-κB pathway, and deregulate p53 and B-cell transcription factors.
UR - https://www.scopus.com/pages/publications/84897510639
UR - https://www.scopus.com/pages/publications/84897510639#tab=citedBy
U2 - 10.1182/blood-2013-05-500595
DO - 10.1182/blood-2013-05-500595
M3 - Article
C2 - 24037725
AN - SCOPUS:84897510639
SN - 0006-4971
VL - 123
SP - 1681
EP - 1690
JO - Blood
JF - Blood
IS - 11
ER -