Genome screen for asthma and bronchial hyperresponsiveness: Interactions with passive smoke exposure

Deborah A. Meyers, Dirkje S. Postma, O. Colin Stine, Gerard H. Koppelman, Elizabeth J. Ampleford, Hajo Jongepier, Timothy D. Howard, Eugene R. Bleecker

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma. Objective: We sought to perform a genome-wide linkage screen for asthma and bronchial hyperresponsiveness (BHR) and to determine the influence of passive tobacco smoke exposure during childhood on the results of genetic linkage studies to investigate gene-environment interactions. Methods: A genome-wide linkage screen for asthma and BHR was performed in 200 families ascertained through a parent with asthma. Analyses were performed separately for the entire sample and for the smoking-exposed and nonexposed families. For asthma and BHR, the strongest evidence for linkage was observed for chromosomes 3p and 5q. The families in which the children were exposed to passive smoking accounted for the evidence for linkage of BHR to 5q (P <. 001), but evidence for linkage to 3p was found in both sets of families. Similar results were observed for asthma. However, there was no observed difference in the frequency of asthma or BHR in the offspring from the smoke-exposed compared with the nonexposed families. Conclusion: The results from this study demonstrate that the influence of susceptibility genes for a common disease such as asthma might not be apparent unless there is the appropriate exposure to environmental stimuli, such as passive exposure to cigarette smoke. This approach should be useful for identification of asthma susceptibility genes.

Original languageEnglish (US)
Pages (from-to)1169-1175
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume115
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • Asthma
  • Bronchial hyperresponsiveness
  • Genome-wide screen
  • Linkage
  • Lung function
  • Smoking

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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