Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA)

M. N. Blumenthal; C. Ober; T. H. Beaty; E. R. Bleecker; C. D. Langefeld; R. A. King; L. Lester; N. Cox; K. Barnes; A. Togias; R. Mathias; D. A. Meyers; W. Oetting; S. S. Rich; Eva Ehrlich; Linda Freidhoff; Beverly Plunkett; Maria Stockton; Rhonda Peterson; Jennifer Anderson; Heidi Gidley; Lisa Daniels; Edward Corazalla; Marcia Brott; June Pierce; Mark Brown; Adrienne Hill; Cralen Davis; Tim Howard; Jianfeng Xu

doi:10.1038/sj.gene.6364063

Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA)

M. N. Blumenthal, C. Ober, T. H. Beaty, E. R. Bleecker, C. D. Langefeld, R. A. King, L. Lester, N. Cox, K. Barnes, A. Togias, R. Mathias, D. A. Meyers, W. Oetting, S. S. Rich, Eva Ehrlich, Linda Freidhoff, Beverly Plunkett, Maria Stockton, Rhonda Peterson, Jennifer AndersonHeidi Gidley, Lisa Daniels, Edward Corazalla, Marcia Brott, June Pierce, Mark Brown, Adrienne Hill, Cralen Davis, Tim Howard, Jianfeng Xu

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P = 0.0008; D19S1037, lod = 1.57, P= 0.007) and chromosome 20 (D20S473/D20S604, lod= 1.41, P= 0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod= 1.33, P = 0.01), 12 (D12S373, lod= 1.51, P= 0.008) and 18 (ATA82B02, lod= 1.32, P= 0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod= 3.51, P = 0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod= 1.56, P= 0.007), 13 (D13S787, lod= 1.30, P= 0.01) and 20 (D20S470, lod= 1.71, P= 0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.

Original language	English (US)
Pages (from-to)	226-231
Number of pages	6
Journal	Genes and Immunity
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/sj.gene.6364063
State	Published - May 2004
Externally published	Yes

Keywords

Asthma
Atopy
Genome scan
Mite sensitivity

ASJC Scopus subject areas

Immunology
Genetics
Genetics(clinical)

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10.1038/sj.gene.6364063

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Blumenthal, M. N., Ober, C., Beaty, T. H., Bleecker, E. R., Langefeld, C. D., King, R. A., Lester, L., Cox, N., Barnes, K., Togias, A., Mathias, R., Meyers, D. A., Oetting, W., Rich, S. S., Ehrlich, E., Freidhoff, L., Plunkett, B., Stockton, M., Peterson, R., ... Xu, J. (2004). Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA). Genes and Immunity, 5(3), 226-231. https://doi.org/10.1038/sj.gene.6364063

Blumenthal, MN, Ober, C, Beaty, TH, Bleecker, ER, Langefeld, CD, King, RA, Lester, L, Cox, N, Barnes, K, Togias, A, Mathias, R, Meyers, DA, Oetting, W, Rich, SS, Ehrlich, E, Freidhoff, L, Plunkett, B, Stockton, M, Peterson, R, Anderson, J, Gidley, H, Daniels, L, Corazalla, E, Brott, M, Pierce, J, Brown, M, Hill, A, Davis, C, Howard, T & Xu, J 2004, 'Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA)', Genes and Immunity, vol. 5, no. 3, pp. 226-231. https://doi.org/10.1038/sj.gene.6364063

@article{7c2009cf780243bb869b3687104a583d,

title = "Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA)",

abstract = "Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P = 0.0008; D19S1037, lod = 1.57, P= 0.007) and chromosome 20 (D20S473/D20S604, lod= 1.41, P= 0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod= 1.33, P = 0.01), 12 (D12S373, lod= 1.51, P= 0.008) and 18 (ATA82B02, lod= 1.32, P= 0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod= 3.51, P = 0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod= 1.56, P= 0.007), 13 (D13S787, lod= 1.30, P= 0.01) and 20 (D20S470, lod= 1.71, P= 0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.",

keywords = "Asthma, Atopy, Genome scan, Mite sensitivity",

author = "Blumenthal, {M. N.} and C. Ober and Beaty, {T. H.} and Bleecker, {E. R.} and Langefeld, {C. D.} and King, {R. A.} and L. Lester and N. Cox and K. Barnes and A. Togias and R. Mathias and Meyers, {D. A.} and W. Oetting and Rich, {S. S.} and Eva Ehrlich and Linda Freidhoff and Beverly Plunkett and Maria Stockton and Rhonda Peterson and Jennifer Anderson and Heidi Gidley and Lisa Daniels and Edward Corazalla and Marcia Brott and June Pierce and Mark Brown and Adrienne Hill and Cralen Davis and Tim Howard and Jianfeng Xu",

note = "Funding Information: This study was supported by the following NIH Grants: U01 HL49612 (JHU), U01 HL49596 and M01 RR00055 (UC), U01 HL59609 and M01 RR00400 (UMN), U01 HL58977, U01 HL49602, U01 HL49609 and M01 RR00600 (University of Maryland and Wake Forest University), HV-48141 (Mammalian Genotyping Service) and HRRC 93-196 (University of New Mexico). In addition to the authors, other coinvestigators and key support personnel for the CSGA includes: Eva Ehrlich, Linda Freidhoff, Rasika Mathias, Beverly Plunkett and Maria Stockton (Johns Hopkins University), Rhonda Peterson, Jennifer Anderson and Heidi Gidley (University of Chicago), Lisa Daniels, Edward Corazalla and Marcia Brott (University of Minnesota), June Pierce, Mark Brown, Adrienne Hill and Cralen Davis (Wake Forest University Data Coordinating Center) and Tim Howard and Jianfeng Xu (Wake Forest University).",

year = "2004",

month = may,

doi = "10.1038/sj.gene.6364063",

language = "English (US)",

volume = "5",

pages = "226--231",

journal = "Genes and Immunity",

issn = "1466-4879",

publisher = "Springer Nature",

number = "3",

}

TY - JOUR

T1 - Genome scan for loci linked to mite sensitivity

T2 - The Collaborative Study on the Genetics of Asthma (CSGA)

AU - Blumenthal, M. N.

AU - Ober, C.

AU - Beaty, T. H.

AU - Bleecker, E. R.

AU - Langefeld, C. D.

AU - King, R. A.

AU - Lester, L.

AU - Cox, N.

AU - Barnes, K.

AU - Togias, A.

AU - Mathias, R.

AU - Meyers, D. A.

AU - Oetting, W.

AU - Rich, S. S.

AU - Ehrlich, Eva

AU - Freidhoff, Linda

AU - Plunkett, Beverly

AU - Stockton, Maria

AU - Peterson, Rhonda

AU - Anderson, Jennifer

AU - Gidley, Heidi

AU - Daniels, Lisa

AU - Corazalla, Edward

AU - Brott, Marcia

AU - Pierce, June

AU - Brown, Mark

AU - Hill, Adrienne

AU - Davis, Cralen

AU - Howard, Tim

AU - Xu, Jianfeng

N1 - Funding Information: This study was supported by the following NIH Grants: U01 HL49612 (JHU), U01 HL49596 and M01 RR00055 (UC), U01 HL59609 and M01 RR00400 (UMN), U01 HL58977, U01 HL49602, U01 HL49609 and M01 RR00600 (University of Maryland and Wake Forest University), HV-48141 (Mammalian Genotyping Service) and HRRC 93-196 (University of New Mexico). In addition to the authors, other coinvestigators and key support personnel for the CSGA includes: Eva Ehrlich, Linda Freidhoff, Rasika Mathias, Beverly Plunkett and Maria Stockton (Johns Hopkins University), Rhonda Peterson, Jennifer Anderson and Heidi Gidley (University of Chicago), Lisa Daniels, Edward Corazalla and Marcia Brott (University of Minnesota), June Pierce, Mark Brown, Adrienne Hill and Cralen Davis (Wake Forest University Data Coordinating Center) and Tim Howard and Jianfeng Xu (Wake Forest University).

PY - 2004/5

Y1 - 2004/5

N2 - Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P = 0.0008; D19S1037, lod = 1.57, P= 0.007) and chromosome 20 (D20S473/D20S604, lod= 1.41, P= 0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod= 1.33, P = 0.01), 12 (D12S373, lod= 1.51, P= 0.008) and 18 (ATA82B02, lod= 1.32, P= 0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod= 3.51, P = 0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod= 1.56, P= 0.007), 13 (D13S787, lod= 1.30, P= 0.01) and 20 (D20S470, lod= 1.71, P= 0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.

AB - Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P = 0.0008; D19S1037, lod = 1.57, P= 0.007) and chromosome 20 (D20S473/D20S604, lod= 1.41, P= 0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod= 1.33, P = 0.01), 12 (D12S373, lod= 1.51, P= 0.008) and 18 (ATA82B02, lod= 1.32, P= 0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod= 3.51, P = 0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod= 1.56, P= 0.007), 13 (D13S787, lod= 1.30, P= 0.01) and 20 (D20S470, lod= 1.71, P= 0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.

KW - Asthma

KW - Atopy

KW - Genome scan

KW - Mite sensitivity

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JF - Genes and Immunity

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ER -

Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA)

Abstract

Keywords

ASJC Scopus subject areas

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