Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA)

M. N. Blumenthal, C. Ober, T. H. Beaty, E. R. Bleecker, C. D. Langefeld, R. A. King, L. Lester, N. Cox, K. Barnes, A. Togias, R. Mathias, D. A. Meyers, W. Oetting, S. S. Rich, Eva Ehrlich, Linda Freidhoff, Beverly Plunkett, Maria Stockton, Rhonda Peterson, Jennifer AndersonHeidi Gidley, Lisa Daniels, Edward Corazalla, Marcia Brott, June Pierce, Mark Brown, Adrienne Hill, Cralen Davis, Tim Howard, Jianfeng Xu

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P = 0.0008; D19S1037, lod = 1.57, P= 0.007) and chromosome 20 (D20S473/D20S604, lod= 1.41, P= 0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod= 1.33, P = 0.01), 12 (D12S373, lod= 1.51, P= 0.008) and 18 (ATA82B02, lod= 1.32, P= 0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod= 3.51, P = 0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod= 1.56, P= 0.007), 13 (D13S787, lod= 1.30, P= 0.01) and 20 (D20S470, lod= 1.71, P= 0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.

Original languageEnglish (US)
Pages (from-to)226-231
Number of pages6
JournalGenes and Immunity
Issue number3
StatePublished - May 2004
Externally publishedYes


  • Asthma
  • Atopy
  • Genome scan
  • Mite sensitivity

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)


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