Genetics of post-traumatic stress disorder and sleep disturbance

We will begin by providing a brief summary of the sleep and post-traumatic stress disorder (PTSD) literature in veterans, followed by an overview of common genetic methods utilized across studies. Next, we will provide a summary of the vast PTSD genetic literature, followed by a review of the sleep genetic literature with a focus on insomnia and related sleep symptoms. Although there are no molecular genetic studies to date examining the overlap between sleep and PTSD, we compare the literature with a focus on hypothesized genes that may contribute to the comorbidity of these conditions. The chapter will finish with a summary of key gaps in the literature and future directions that can address these concerns.