Genetics of IL-13 and functional relevance of IL-13 variants

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Studies in both humans and mice clearly show that interleukin (IL)-13 is a central regulator of allergic inflammation. Numerous single nucleotide polymorphisms have been recently identified in the IL-13 gene and have been found to be associated with allergic and/or asthmatic phenotypes in different populations throughout the world. Furthermore, functional genomics studies are highlighting mechanistic pathways that may link genetic variation in IL-13 and disease. IL-13 is therefore an ideal model to study the impact of genetic variation on the regulation of gene expression and function in complex diseases.

Original languageEnglish (US)
Pages (from-to)389-393
Number of pages5
JournalCurrent opinion in allergy and clinical immunology
Issue number5
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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