Genetics of Asthma Susceptibility and Severity

Rebecca E. Slager, Gregory A. Hawkins, Xingnan Li, Dirkje S. Postma, Deborah A. Meyers, Eugene R. Bleecker

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.

Original languageEnglish (US)
Pages (from-to)431-443
Number of pages13
JournalClinics in Chest Medicine
Volume33
Issue number3
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • Asthma
  • Genetics
  • Lung function
  • Personalized medicine
  • Severity
  • Susceptibility
  • Therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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