Genetics of Asthma Susceptibility and Severity

Rebecca E. Slager; Gregory A. Hawkins; Xingnan Li; Dirkje S. Postma; Deborah A. Meyers; Eugene R. Bleecker

doi:10.1016/j.ccm.2012.05.005

Genetics of Asthma Susceptibility and Severity

Rebecca E. Slager, Gregory A. Hawkins, Xingnan Li, Dirkje S. Postma, Deborah A. Meyers, Eugene R. Bleecker

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.

Original language	English (US)
Pages (from-to)	431-443
Number of pages	13
Journal	Clinics in Chest Medicine
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.ccm.2012.05.005
State	Published - Sep 2012
Externally published	Yes

Keywords

Asthma
Genetics
Lung function
Personalized medicine
Severity
Susceptibility
Therapy

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.ccm.2012.05.005

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title = "Genetics of Asthma Susceptibility and Severity",

abstract = "This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.",

keywords = "Asthma, Genetics, Lung function, Personalized medicine, Severity, Susceptibility, Therapy",

author = "Slager, {Rebecca E.} and Hawkins, {Gregory A.} and Xingnan Li and Postma, {Dirkje S.} and Meyers, {Deborah A.} and Bleecker, {Eugene R.}",

note = "Funding Information: Financial disclosure: This work was funded by NHLBI grants HL69167 and HL101487 . RES was supported by HL089992 and HL101487. ",

year = "2012",

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doi = "10.1016/j.ccm.2012.05.005",

language = "English (US)",

volume = "33",

pages = "431--443",

journal = "Clinics in Chest Medicine",

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T1 - Genetics of Asthma Susceptibility and Severity

AU - Slager, Rebecca E.

AU - Hawkins, Gregory A.

AU - Li, Xingnan

AU - Postma, Dirkje S.

AU - Meyers, Deborah A.

AU - Bleecker, Eugene R.

N1 - Funding Information: Financial disclosure: This work was funded by NHLBI grants HL69167 and HL101487 . RES was supported by HL089992 and HL101487.

PY - 2012/9

Y1 - 2012/9

N2 - This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.

AB - This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.

KW - Asthma

KW - Genetics

KW - Lung function

KW - Personalized medicine

KW - Severity

KW - Susceptibility

KW - Therapy

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DO - 10.1016/j.ccm.2012.05.005

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AN - SCOPUS:84865561636

SN - 0272-5231

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EP - 443

JO - Clinics in Chest Medicine

JF - Clinics in Chest Medicine

IS - 3

ER -

Genetics of Asthma Susceptibility and Severity

Abstract

Keywords

ASJC Scopus subject areas

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