Genetics of allergy and bronchial hyperresponsiveness

T. D. Howard, D. G. Wiesch, G. H. Koppelman, D. S. Postma, D. A. Meyers, E. R. Bleecker

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Allergy and asthma are closely related complex diseases caused by a combination of both genetic and environmental influences. Two common genetic approaches, candidate gene studies and genome-wide screens, have been used to localize and evaluate potential genetic factors that confer susceptibility or modify the phenotype of these diseases. Four genome screens suggest multiple chromosomal locations likely to contain asthma and allergy genes and many potential candidate genes exist in these regions. These screens were performed in six different populations and identified many common susceptibility regions as well as novel regions for each population. Ideally, these genes may point towards key biological pathways that will eventually serve as targets for therapeutic agents.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalClinical and Experimental Allergy, Supplement
Issue number2
StatePublished - 1999
Externally publishedYes


  • Allergy
  • Asthma
  • Bronchial hyperresponsiveness
  • Candidate genes
  • Genome screens
  • IgE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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