Geneticpolymorphism of SERPING1 rs2511989 and age-related macular degeneration: a Meta-analysis

Yu Qin, Jiang Yue Zhao, Chun Shu Pan, Xue Fei He, Xiao Jie Min, Ming Wu Wang, Qi Chang Yan, Di Wu, Jing Li, Xin Wei Wu, Jin Song Zhang

Research output: Contribution to journalArticlepeer-review


AIM: To explore the association between the polymorphism rs2511989 in the classical pathway geneSERPING1 (C1 inhibitor) and age-related macular degeneration (AMD). METHODS: A random-effect Meta-analysis was performed. An electronic search was done in CNKI, PubMed, the Cochrane Collaboration's Database, Embase, and the ISI Web of Knowledge. Odds ratios (OR) and their 95% confidence interval (CI) were calculated to assess the strength of association between SERPING1 rs2511989 polymorphism and AMD susceptibility. Heterogeneity, sensitivity analysis and publication bias were also tested. RESULTS: A total of 15 case-control studies with 8657 cases and 5393 controls were finally included in this Meta-analysis. There was no significant association between SERPING1 and AMD in all genetic models. (Dominant model: OR=0.960, 95%CI: 0.918-1.003, P=0.009; recessive model: OR=0.898, 95%CI: 0.791-1.019, P=0.035; homozygote model: OR=0.881, 95%CI: 0.770-1.008, P=0.003; heterozygote model: OR=0.962, 95%CI: 0.917-1.010, P=0.050). However, the associations between SERPING1 and neovascular AMD were significant in three models (dominant model: OR=0.691, 95%CI: 0.547-0.872; homozygote model: OR=0.661, 95%CI: 0.450-0.971; heterozygote model: OR=0.754, 95%CI: 0.589-0.964). Subgroup analysis by ethnicity and country did not find significant association between rs2511989 polymorphism and AMD susceptibility. CONCLUSION: SERPING1 rs2511989 does not associates with AMD generally but may associate with neovascular AMD. More studies are required to verify the hypothesis.

Original languageEnglish (US)
Pages (from-to)944-949
Number of pages6
JournalInternational Eye Science
Issue number6
StatePublished - Jun 8 2015


  • Age-related macular degeneration
  • Meta-analysis
  • Polymorphism

ASJC Scopus subject areas

  • Ophthalmology


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