Genetically modified rodent models: A new generation of translational cognitive science

Salvatore Oddo; Masashi Kitazawa

doi:10.1007/978-1-4939-2159-1_9

Genetically modified rodent models: A new generation of translational cognitive science

Salvatore Oddo, Masashi Kitazawa

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The brain is the key organ that differentiates humans from each other and from other animals; it stores personal experiences and knowledge in the form of memories, integrates all external information, and controls fundamental functions for survival. The underlying molecular mechanisms of learning and memory, and maintaining such high plasticity and flexibility in the brain, have remained long-lasting mysteries in the field of neuroscience. This chapter primarily focuses on the role of neurons and signal transduction pathways within the neuronal cells in learning and memory, and details the procedures used for generating genetically modified rodents. Also discussed is the application of knockout and knock-in models to understand the underlying molecular mechanisms of learning and memory, as well as the advantages and limitations of their use.

Original language	English (US)
Title of host publication	The Maze Book
Subtitle of host publication	Theories, Practice, and Protocols for Testing Rodent Cognition
Publisher	Springer New York
Pages	259-283
Number of pages	25
ISBN (Electronic)	9781493921591
ISBN (Print)	9781493921584
DOIs	https://doi.org/10.1007/978-1-4939-2159-1_9
State	Published - Mar 10 2015
Externally published	Yes

Keywords

Animal model, transgenic
Behavior
Brain
Gene modification
Genetic
Knock-in
Knockout
Learning
Mutation
Pathology
Signal transduction

ASJC Scopus subject areas

General Agricultural and Biological Sciences

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10.1007/978-1-4939-2159-1_9

Cite this

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abstract = "The brain is the key organ that differentiates humans from each other and from other animals; it stores personal experiences and knowledge in the form of memories, integrates all external information, and controls fundamental functions for survival. The underlying molecular mechanisms of learning and memory, and maintaining such high plasticity and flexibility in the brain, have remained long-lasting mysteries in the field of neuroscience. This chapter primarily focuses on the role of neurons and signal transduction pathways within the neuronal cells in learning and memory, and details the procedures used for generating genetically modified rodents. Also discussed is the application of knockout and knock-in models to understand the underlying molecular mechanisms of learning and memory, as well as the advantages and limitations of their use.",

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AB - The brain is the key organ that differentiates humans from each other and from other animals; it stores personal experiences and knowledge in the form of memories, integrates all external information, and controls fundamental functions for survival. The underlying molecular mechanisms of learning and memory, and maintaining such high plasticity and flexibility in the brain, have remained long-lasting mysteries in the field of neuroscience. This chapter primarily focuses on the role of neurons and signal transduction pathways within the neuronal cells in learning and memory, and details the procedures used for generating genetically modified rodents. Also discussed is the application of knockout and knock-in models to understand the underlying molecular mechanisms of learning and memory, as well as the advantages and limitations of their use.

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KW - Learning

KW - Mutation

KW - Pathology

KW - Signal transduction

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Genetically modified rodent models: A new generation of translational cognitive science

Abstract

Keywords

ASJC Scopus subject areas

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