Genetic polymorphism in allergy and asthma

Donata Vercelli

doi:10.1016/j.coi.2003.09.005

Genetic polymorphism in allergy and asthma

Donata Vercelli

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

The impact of genetic factors on the pathogenesis of allergy and asthma is currently an area of intense investigation. Although epidemiological studies find more and more genes that are likely to contribute to allergic inflammation, functional studies of the mechanisms that link genetic variation with dysregulation of gene expression and function are hindered by the high frequency of natural variation. The interplay between genes and environment adds another layer of complexity to the determination of allergic phenotypes. The complexity emerging from these studies warrants novel experimental strategies and bolder conceptual paradigms.

Original language	English (US)
Pages (from-to)	609-613
Number of pages	5
Journal	Current Opinion in Immunology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.coi.2003.09.005
State	Published - Dec 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.coi.2003.09.005

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title = "Genetic polymorphism in allergy and asthma",

abstract = "The impact of genetic factors on the pathogenesis of allergy and asthma is currently an area of intense investigation. Although epidemiological studies find more and more genes that are likely to contribute to allergic inflammation, functional studies of the mechanisms that link genetic variation with dysregulation of gene expression and function are hindered by the high frequency of natural variation. The interplay between genes and environment adds another layer of complexity to the determination of allergic phenotypes. The complexity emerging from these studies warrants novel experimental strategies and bolder conceptual paradigms.",

author = "Donata Vercelli",

note = "Funding Information: The author was supported by grants PO1HL67672 and RO1HL66391 from the National Institutes of Health, and by the Program for Genomic Applications Innate Immunity in Heart, Lung and Blood Disease (U01-HL66803) from the National Heart, Lung and Blood Institute.",

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PY - 2003/12

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N2 - The impact of genetic factors on the pathogenesis of allergy and asthma is currently an area of intense investigation. Although epidemiological studies find more and more genes that are likely to contribute to allergic inflammation, functional studies of the mechanisms that link genetic variation with dysregulation of gene expression and function are hindered by the high frequency of natural variation. The interplay between genes and environment adds another layer of complexity to the determination of allergic phenotypes. The complexity emerging from these studies warrants novel experimental strategies and bolder conceptual paradigms.

AB - The impact of genetic factors on the pathogenesis of allergy and asthma is currently an area of intense investigation. Although epidemiological studies find more and more genes that are likely to contribute to allergic inflammation, functional studies of the mechanisms that link genetic variation with dysregulation of gene expression and function are hindered by the high frequency of natural variation. The interplay between genes and environment adds another layer of complexity to the determination of allergic phenotypes. The complexity emerging from these studies warrants novel experimental strategies and bolder conceptual paradigms.

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Genetic polymorphism in allergy and asthma

Abstract

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