Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent

Jabril R. Johnson, Leanne Woods-Burnham, Stanley E. Hooker, Ken Batai, Rick A. Kittles

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Prostate cancer (PCa) is the second most frequently diagnosed malignancy and the second leading cause of death in men worldwide, after adjusting for age. According to the International Agency for Research on Cancer, continents such as North America and Europe report higher incidence of PCa; however, mortality rates are highest among men of African ancestry in the western, southern, and central regions of Africa and the Caribbean. The American Cancer Society reports, African Americans (AAs), in the United States, have a 1.7 increased incidence and 2.4 times higher mortality rate, compared to European American’s (EAs). Hence, early population history in west Africa and the subsequent African Diaspora may play an important role in understanding the global disproportionate burden of PCa shared among Africans and other men of African descent. Nonetheless, disparities involved in diagnosis, treatment, and survival of PCa patients has also been correlated to socioeconomic status, education and access to healthcare. Although recent studies suggest equal PCa treatments yield equal outcomes among patients, data illuminates an unsettling reality of disparities in treatment and care in both, developed and developing countries, especially for men of African descent. Yet, even after adjusting for the effects of the aforementioned factors; racial disparities in mortality rates remain significant. This suggests that molecular and genomic factors may account for much of PCa disparities.

Original languageEnglish (US)
Article number770500
JournalFrontiers in Oncology
Volume11
DOIs
StatePublished - Nov 8 2021

Keywords

  • GWAS
  • Vitamin D
  • genetics
  • precision medicine
  • prostate cancer disparities
  • prostate cancer genetics
  • prostate cancer screening
  • socioeconomic status

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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