Genetic and molecular mechanisms of chemical atherogenesis

Kenneth S. Ramos; Charles R. Partridge; Ivo Teneng

doi:10.1016/j.mrfmmm.2006.12.009

Genetic and molecular mechanisms of chemical atherogenesis

Kenneth S. Ramos, Charles R. Partridge, Ivo Teneng

Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Injury to the cellular components of the vascular wall and blood by endogenous and exogenous chemicals has been associated with atherosclerosis in humans and experimental systems. The genetic and molecular mechanisms responsible for initiation and promotion of atherosclerotic changes include modulation of extracellular matrix-integrin axis, genes involved in the regulation of growth and differentiation and possibly, genomic stability. This review summarizes seminal studies over the past 20 years that shed light on critical gene-gene and gene-environment interactions mediating the atherogenic response to chemical injury.

Original language	English (US)
Pages (from-to)	18-30
Number of pages	13
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	621
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mrfmmm.2006.12.009
State	Published - Aug 1 2007

Keywords

Atherosclerosis
Chemical injury
Genetics
LINE-1
Osteopontin

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

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10.1016/j.mrfmmm.2006.12.009

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AU - Partridge, Charles R.

AU - Teneng, Ivo

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AB - Injury to the cellular components of the vascular wall and blood by endogenous and exogenous chemicals has been associated with atherosclerosis in humans and experimental systems. The genetic and molecular mechanisms responsible for initiation and promotion of atherosclerotic changes include modulation of extracellular matrix-integrin axis, genes involved in the regulation of growth and differentiation and possibly, genomic stability. This review summarizes seminal studies over the past 20 years that shed light on critical gene-gene and gene-environment interactions mediating the atherogenic response to chemical injury.

KW - Atherosclerosis

KW - Chemical injury

KW - Genetics

KW - LINE-1

KW - Osteopontin

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Genetic and molecular mechanisms of chemical atherogenesis

Abstract

Keywords

ASJC Scopus subject areas

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