Generation of the [NiFe] hydrogenase active site (sulfur's the one!)

Richard S. Glass; Athanasios Paschos; Stephanie Reissmann; M. S. Singh; Haofan Wang; August Böck

doi:10.1080/10426500590910774

Generation of the [NiFe] hydrogenase active site (sulfur's the one!)

Richard S. Glass
, Athanasios Paschos
, Stephanie Reissmann
, M. S. Singh
, Haofan Wang
, August Böck

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Chemical and biochemical methods were used to unravel the unprecedented pathway by which the CN ligands of iron in [NiFe] hydrogenase are introduced. Carbamoyl phosphate is the one carbon precursor of these ligands, and reactions involving a protein cysteinyl sulfur are key for processing this precursor into CN ligands.

Original language	English (US)
Pages (from-to)	1183-1185
Number of pages	3
Journal	Phosphorus, Sulfur and Silicon and the Related Elements
Volume	180
Issue number	5-6
DOIs	https://doi.org/10.1080/10426500590910774
State	Published - 2005
Externally published	Yes

Keywords

Carbamoyl phosphate
Thiocarbamate, thiocyanate
[NiFe] hydrogenase biosynthesis

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Inorganic Chemistry

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10.1080/10426500590910774

Cite this

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title = "Generation of the [NiFe] hydrogenase active site (sulfur's the one!)",

abstract = "Chemical and biochemical methods were used to unravel the unprecedented pathway by which the CN ligands of iron in [NiFe] hydrogenase are introduced. Carbamoyl phosphate is the one carbon precursor of these ligands, and reactions involving a protein cysteinyl sulfur are key for processing this precursor into CN ligands.",

keywords = "Carbamoyl phosphate, Thiocarbamate, thiocyanate, [NiFe] hydrogenase biosynthesis",

author = "Glass, \{Richard S.\} and Athanasios Paschos and Stephanie Reissmann and Singh, \{M. S.\} and Haofan Wang and August B{\"o}ck",

note = "Funding Information: We gratefully acknowledge support of this work by the Deutsche Forschungsgemein-schaft, Fonds der Chemischen Industrie (A.B.), and the donors of the Petroleum Research Fund, administered by the American Chemical Society (R. S. G., M. S. S., H. W.) for support of this research. The authors thank Dr. Friedrich Lottspeich and Elizabeth Hochleit-ner of the Max-Planck Institute for Biochemistry, Martinsried, Germany, for technical assistance with the mass spectral studies.",

year = "2005",

doi = "10.1080/10426500590910774",

language = "English (US)",

volume = "180",

pages = "1183--1185",

journal = "Phosphorus, Sulfur and Silicon and the Related Elements",

issn = "1042-6507",

publisher = "Taylor and Francis Ltd.",

number = "5-6",

}

TY - JOUR

T1 - Generation of the [NiFe] hydrogenase active site (sulfur's the one!)

AU - Glass, Richard S.

AU - Paschos, Athanasios

AU - Reissmann, Stephanie

AU - Singh, M. S.

AU - Wang, Haofan

AU - Böck, August

N1 - Funding Information: We gratefully acknowledge support of this work by the Deutsche Forschungsgemein-schaft, Fonds der Chemischen Industrie (A.B.), and the donors of the Petroleum Research Fund, administered by the American Chemical Society (R. S. G., M. S. S., H. W.) for support of this research. The authors thank Dr. Friedrich Lottspeich and Elizabeth Hochleit-ner of the Max-Planck Institute for Biochemistry, Martinsried, Germany, for technical assistance with the mass spectral studies.

PY - 2005

Y1 - 2005

N2 - Chemical and biochemical methods were used to unravel the unprecedented pathway by which the CN ligands of iron in [NiFe] hydrogenase are introduced. Carbamoyl phosphate is the one carbon precursor of these ligands, and reactions involving a protein cysteinyl sulfur are key for processing this precursor into CN ligands.

AB - Chemical and biochemical methods were used to unravel the unprecedented pathway by which the CN ligands of iron in [NiFe] hydrogenase are introduced. Carbamoyl phosphate is the one carbon precursor of these ligands, and reactions involving a protein cysteinyl sulfur are key for processing this precursor into CN ligands.

KW - Carbamoyl phosphate

KW - Thiocarbamate, thiocyanate

KW - [NiFe] hydrogenase biosynthesis

UR - https://www.scopus.com/pages/publications/27244448950

UR - https://www.scopus.com/pages/publications/27244448950#tab=citedBy

U2 - 10.1080/10426500590910774

DO - 10.1080/10426500590910774

M3 - Article

AN - SCOPUS:27244448950

SN - 1042-6507

VL - 180

SP - 1183

EP - 1185

JO - Phosphorus, Sulfur and Silicon and the Related Elements

JF - Phosphorus, Sulfur and Silicon and the Related Elements

IS - 5-6

ER -

Generation of the [NiFe] hydrogenase active site (sulfur's the one!)

Abstract

Keywords

ASJC Scopus subject areas

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