@inbook{46ba419d4a47444da492fb5d70071226,
title = "Generation and use of gastric organoids for the study of Helicobacter pylori pathogenesis",
abstract = "While the incidence of gastric cancer in the United States is relatively low due to the diagnosis and treatment of the major risk factor Helicobacter pylori (H. pylori), 5-year patient survival is only approximately 29%. Even after H. pylori infection has been eradicated there is still a risk of developing gastric cancer. Gastric cancer is the final clinical outcome that is often initiated by a sustained inflammatory response and altered epithelial cell differentiation and metaplasia in response to H. pylori infection. Identifying the early epithelial responses to H. pylori infection is important in advancing our understanding of the events that shape a conducive environment for the progression of gastric cancer. Thus, we developed a human gastric tissue-derived organoid-based approach to identify the initiating molecular events that trigger gastric cancer development in response to bacterial infection.",
keywords = "Gastric cancer, Gastric metaplasia, Gastritis, Helicobacter, Organoid",
author = "Jayati Chakrabarti and Yana Zavros",
note = "Funding Information: We are sincerely grateful for the collaboration and support by Dr. James Wells (Division of Developmental Biology, Center for Stem Cell & Organoid Medicine, Division of Endocrinology, Cincinnati Children's Hospital Medical Center) and Dr. Michael Helmrath (Department of Pediatric Surgery, Cincinnati Children's Hospital Medical Center). We also thank Dr. Richard Peek (Vanderbilt University School of Medicine) for the collaboration and support in providing Helicobacter strains and expertise. We would like to acknowledge the past members of the Zavros laboratory Drs. Nina Steele, Loryn Holokai and Emma Teal for their contribution to the development of the organoid culture system. This work was supported by NIH (NIAID) 5U19AI11649105 (PIs: Weiss and Wells, Project Leader 1: Zavros) and NIH R01DK083402-08 (PI: Zavros). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
doi = "10.1016/bs.mcb.2020.04.011",
language = "English (US)",
isbn = "9780128215319",
series = "Methods in Cell Biology",
publisher = "Academic Press Inc.",
pages = "23--46",
editor = "Spence, {Jason R.}",
booktitle = "Human Pluripotent Stem Cell Derived Organoid Models",
}