Generalised eruptive histiocytosis preceded by systemic symptoms

Caitlyn N. Myrdal, Delaney B. Stratton, Tracy L. Davis, Clara Curiel-Lewandrowski

Research output: Contribution to journalArticlepeer-review


Generalised eruptive histiocytosis is a rare proliferative disease that typically presents with indolent cutaneous eruptions. We describe the case of a 73-year-old man presenting with diffuse, asymptomatic crops of pink to dusky red papules preceded by general malaise, myalgias, fluctuating fever, chills, and weight loss. Histological evaluation revealed a non-Langerhans cell histiocytic dermal infiltrate with spindle cell features and chronic inflammation, reactive for CD68 and negative for both S100 and CD1a. Malignancy screening was negative. This report aims to highlight a unique presentation of generalised eruptive histiocytosis, emphasise histological findings, and discuss considerations for malignancy screening.

Original languageEnglish (US)
Article numbere243411
JournalBMJ case reports
Issue number6
StatePublished - Jun 23 2021


  • Dermatology
  • Pathology
  • Screening (oncology)

ASJC Scopus subject areas

  • General Medicine


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