Abstract
An Ugi one-pot three-component four-center reaction was coupled with a subsequent acid mediated cyclodehydration step to furnish a multitude of unique scaffolds having in common an embedded or attached benzimidazole and often a ring system formed through lactamization. Using combinations of tethered Ugi inputs typically via tethered acid-ketone inputs and supporting reagents containing masked internal nucleophiles, such scaffolds were produced in good to excellent yields in an operationally friendly manner.
Original language | English (US) |
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Pages (from-to) | 460-464 |
Number of pages | 5 |
Journal | ACS Combinatorial Science |
Volume | 14 |
Issue number | 8 |
DOIs | |
State | Published - Aug 13 2012 |
Keywords
- Ugi reaction
- benzimidazole
- lactams
- one-pot
- postcondensation
ASJC Scopus subject areas
- Chemistry(all)
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CCDC 908808: Experimental Crystal Structure Determination
Xu, Z. (Creator), Cappelli, A. A. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/cczhpdj, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cczhpdj&sid=DataCite
Dataset
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CCDC 908809: Experimental Crystal Structure Determination
Xu, Z. (Creator), Cappelli, A. A. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/cczhpfk, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cczhpfk&sid=DataCite
Dataset