TY - JOUR
T1 - Genealogical correspondence of mushroom bodies across invertebrate phyla
AU - Wolff, Gabriella H.
AU - Strausfeld, Nicholas J.
N1 - Funding Information:
We thank Nick Gibson, University of Arizona, for providing valuable help with western blot analyses. We would like to once again thank Daniel Kalderon, Columbia University, for his generous donation of anti-DC0 antibody and Ronald Davis for his generation of antisera against Leonardo. N.J.S. thanks Martin Heisenberg for many discussions about insect mushroom bodies. Work was supported by an Alexander von Humboldt Foundation Senior Research Prize to N.J.S. G.H.W. was funded by a National Science Foundation Graduate Research Fellowship Grant (DGE-1143953, 7/15/2011-6/30/2016). Other support came from the Center for Insect Science and grant AFRL FA86511010001 to N.J.S.
Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/1/5
Y1 - 2015/1/5
N2 - Except in species that have undergone evolved loss, paired lobed centers referred to as "mushroom bodies" occur across invertebrate phyla [1-5]. Unresolved is the question of whether these centers, which support learning and memory in insects, correspond genealogically or whether their neuronal organization suggests convergent evolution. Here, anatomical and immunohistological observations demonstrate that across phyla, mushroom body-like centers share a neuroanatomical ground pattern and proteins required for memory formation. Paired lobed or dome-like neuropils characterize the first brain segment (protocerebrum) of mandibulate and chelicerate arthropods and the nonganglionic brains of polychaete annelids, polyclad planarians, and nemerteans. Structural and cladistic analyses resolve an ancestral ground pattern common to all investigated taxa: chemosensory afferents supplying thousands of intrinsic neurons, the parallel processes of which establish orthogonal networks with feedback loops, modulatory inputs, and efferents. Shared ground patterns and their selective labeling with antisera against proteins required for normal mushroom body function in Drosophila are indicative of genealogical correspondence and thus an ancestral presence predating arthropod and lophotrochozoan origins. Implications of this are considered in the context of mushroom body function and early ecologies of ancestral bilaterians.
AB - Except in species that have undergone evolved loss, paired lobed centers referred to as "mushroom bodies" occur across invertebrate phyla [1-5]. Unresolved is the question of whether these centers, which support learning and memory in insects, correspond genealogically or whether their neuronal organization suggests convergent evolution. Here, anatomical and immunohistological observations demonstrate that across phyla, mushroom body-like centers share a neuroanatomical ground pattern and proteins required for memory formation. Paired lobed or dome-like neuropils characterize the first brain segment (protocerebrum) of mandibulate and chelicerate arthropods and the nonganglionic brains of polychaete annelids, polyclad planarians, and nemerteans. Structural and cladistic analyses resolve an ancestral ground pattern common to all investigated taxa: chemosensory afferents supplying thousands of intrinsic neurons, the parallel processes of which establish orthogonal networks with feedback loops, modulatory inputs, and efferents. Shared ground patterns and their selective labeling with antisera against proteins required for normal mushroom body function in Drosophila are indicative of genealogical correspondence and thus an ancestral presence predating arthropod and lophotrochozoan origins. Implications of this are considered in the context of mushroom body function and early ecologies of ancestral bilaterians.
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U2 - 10.1016/j.cub.2014.10.049
DO - 10.1016/j.cub.2014.10.049
M3 - Article
C2 - 25532890
AN - SCOPUS:84920550224
SN - 0960-9822
VL - 25
SP - 38
EP - 44
JO - Current Biology
JF - Current Biology
IS - 1
ER -