Gene-nutrient interactions in nutritional epidemiology

Lenore Kohlmeier, David DeMarini, Walter Piegorsch

Research output: Chapter in Book/Report/Conference proceedingChapter


There is increasing evidence that the ways in which nutrients are handled metabolically is, to a greater or lesser extent, under genetic control. Equally, nutrient (and non-nutrient) intakes affect the expression of genetic predispositions. These complex interactions (nutrient regulation of gene transcription, food-induced DNA damage, phytochemical enhancement or protection of DNA integrity, genetic susceptibility to nutrition-related diseases) increasingly shed light on epidemiological relationships between diet and health and disease. This chapter considers design and analytical implications for understanding gene-nutrient interactions, including specific statistical models. It concludes with a discussion of ethical issues, and an appendix for sample size determination in relation to the determination of genetic characteristics in nutritional epidemiological studies.

Original languageEnglish (US)
Title of host publicationDesign Concepts in Nutritional Epidemiology
PublisherOxford University Press
ISBN (Electronic)9780191723704
ISBN (Print)9780192627391
StatePublished - Sep 1 2009


  • Dna damage
  • Dna integrity
  • Ethics
  • Gene-nutrient interactions
  • Genetics
  • Sample size

ASJC Scopus subject areas

  • General Medicine


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