TY - JOUR
T1 - Gene-environment interactions in asthma and allergies
T2 - A new paradigm to understand disease causation
AU - Martinez, Fernando D.
PY - 2005/11
Y1 - 2005/11
N2 - The example of the complex interactions between environmental exposures and polymorphisms in the CD14 gene in predisposing for allergy-related conditions offers a good indication of the complexity of the mechanisms that determine susceptibility to these conditions. Contrary to what has been the rule for monogenic diseases, the association between genetic variations and polygenic conditions such as asthma and allergies may not always be unidirectional; that is, not always will the same alleles be associated with the conditions under study. Concepts of penetrance of genetic variations that ignore these nonlinear influences (which may affect gene-gene and gene-environment interactions) may hinder a better understanding of the mechanisms of disease involved, and therefore may delay the development of preventive strategies for these common conditions. Discrepancies between well-designed genetic studies of asthma and allergies, therefore, may be suggesting something fundamental about how these diseases develop and how it will be possible to abolish them in the future.
AB - The example of the complex interactions between environmental exposures and polymorphisms in the CD14 gene in predisposing for allergy-related conditions offers a good indication of the complexity of the mechanisms that determine susceptibility to these conditions. Contrary to what has been the rule for monogenic diseases, the association between genetic variations and polygenic conditions such as asthma and allergies may not always be unidirectional; that is, not always will the same alleles be associated with the conditions under study. Concepts of penetrance of genetic variations that ignore these nonlinear influences (which may affect gene-gene and gene-environment interactions) may hinder a better understanding of the mechanisms of disease involved, and therefore may delay the development of preventive strategies for these common conditions. Discrepancies between well-designed genetic studies of asthma and allergies, therefore, may be suggesting something fundamental about how these diseases develop and how it will be possible to abolish them in the future.
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U2 - 10.1016/j.iac.2005.09.001
DO - 10.1016/j.iac.2005.09.001
M3 - Review article
C2 - 16257634
AN - SCOPUS:27644550471
VL - 25
SP - 709
EP - 721
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
SN - 0889-8561
IS - 4
ER -