TY - JOUR
T1 - Gene-Environment Interactions Across Development
T2 - Exploring DRD2 Genotype and Prenatal Smoking Effects on Self-Regulation
AU - Wiebe, Sandra A.
AU - Espy, Kimberly Andrews
AU - Stopp, Christian
AU - Respass, Jennifer
AU - Stewart, Peter
AU - Jameson, Travis R.
AU - Gilbert, David G.
AU - Huggenvik, Jodi I.
PY - 2009/1
Y1 - 2009/1
N2 - Genetic factors dynamically interact with both pre- and postnatal environmental influences to shape development. Considerable attention has been devoted to gene-environment interactions (G × E) on important outcomes (A. Caspi & T. E. Moffitt, 2006). It is also important to consider the possibility that these G × E effects may vary across development, particularly for constructs like self-regulation that emerge slowly, depend on brain regions that change qualitatively in different developmental periods, and thus may be manifested differently. To illustrate one approach to exploring such developmental patterns, the relation between variation in the TaqIA polymorphism, related to D 2 dopamine receptor expression and availability, and prenatal exposure to tobacco was examined in two exploratory studies. First, in 4-week-old neonates, genotype-exposure interactions were observed for attention and irritable reactivity, but not for stress dysregulation. Second, in preschool children, genotype was related to Preschool Trail Making Test (K. A. Espy and M. F. Cwik, 2004) task performance on conditions requiring executive control; children with both the A1+ genotype and a history of prenatal tobacco exposure displayed disproportionately poor performance. Despite study limitations, these results illustrate the importance of examining the interplay between genetic and prenatal environmental factors across development.
AB - Genetic factors dynamically interact with both pre- and postnatal environmental influences to shape development. Considerable attention has been devoted to gene-environment interactions (G × E) on important outcomes (A. Caspi & T. E. Moffitt, 2006). It is also important to consider the possibility that these G × E effects may vary across development, particularly for constructs like self-regulation that emerge slowly, depend on brain regions that change qualitatively in different developmental periods, and thus may be manifested differently. To illustrate one approach to exploring such developmental patterns, the relation between variation in the TaqIA polymorphism, related to D 2 dopamine receptor expression and availability, and prenatal exposure to tobacco was examined in two exploratory studies. First, in 4-week-old neonates, genotype-exposure interactions were observed for attention and irritable reactivity, but not for stress dysregulation. Second, in preschool children, genotype was related to Preschool Trail Making Test (K. A. Espy and M. F. Cwik, 2004) task performance on conditions requiring executive control; children with both the A1+ genotype and a history of prenatal tobacco exposure displayed disproportionately poor performance. Despite study limitations, these results illustrate the importance of examining the interplay between genetic and prenatal environmental factors across development.
KW - dopamine receptor genes
KW - gene-environment interactions
KW - prenatal smoking
KW - self-regulation
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U2 - 10.1037/a0014550
DO - 10.1037/a0014550
M3 - Article
C2 - 19209988
AN - SCOPUS:58449125166
VL - 45
SP - 31
EP - 44
JO - Developmental Psychology
JF - Developmental Psychology
SN - 0012-1649
IS - 1
ER -