Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-β superfamily, is expressed in the hindbrain and epibranchial placodes

Steven A. Vokes; Paul A. Krieg

doi:10.1016/S0925-4773(00)00350-6

Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-β superfamily, is expressed in the hindbrain and epibranchial placodes

Steven A. Vokes, Paul A. Krieg

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	279-282
Number of pages	4
Journal	Mechanisms of Development
Volume	95
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(00)00350-6
State	Published - Jul 1 2000
Externally published	Yes

Keywords

Diencephalon
Epibranchial placodes
Gdf16
Growth/differentiation factor
Hindbrain
TGF-β

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(00)00350-6

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title = "Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-β superfamily, is expressed in the hindbrain and epibranchial placodes",

abstract = "We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Diencephalon, Epibranchial placodes, Gdf16, Growth/differentiation factor, Hindbrain, TGF-β",

author = "Vokes, {Steven A.} and Krieg, {Paul A.}",

note = "Funding Information: We would like to thank Nancy Papalopulu for assistance in identifying neural structures, Eric Lader for performing 5′ RACE and Michael King for providing the stage 42 library. We also thank Eric Small for critical reading of the manuscript, F. Rosa for providing us with a zebrafish radar construct and Robert Reed for assistance with the phylogenetic analysis. This research was supported by NHLBI, NIH grants #HL64763 and #HL64764 to P.A.K.",

year = "2000",

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doi = "10.1016/S0925-4773(00)00350-6",

language = "English (US)",

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pages = "279--282",

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T1 - Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-β superfamily, is expressed in the hindbrain and epibranchial placodes

AU - Vokes, Steven A.

AU - Krieg, Paul A.

N1 - Funding Information: We would like to thank Nancy Papalopulu for assistance in identifying neural structures, Eric Lader for performing 5′ RACE and Michael King for providing the stage 42 library. We also thank Eric Small for critical reading of the manuscript, F. Rosa for providing us with a zebrafish radar construct and Robert Reed for assistance with the phylogenetic analysis. This research was supported by NHLBI, NIH grants #HL64763 and #HL64764 to P.A.K.

PY - 2000/7/1

Y1 - 2000/7/1

N2 - We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Diencephalon

KW - Epibranchial placodes

KW - Gdf16

KW - Growth/differentiation factor

KW - Hindbrain

KW - TGF-β

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DO - 10.1016/S0925-4773(00)00350-6

M3 - Article

C2 - 10906478

AN - SCOPUS:0034235203

SN - 0925-4773

VL - 95

SP - 279

EP - 282

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1-2

ER -

Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-β superfamily, is expressed in the hindbrain and epibranchial placodes

Abstract

Keywords

ASJC Scopus subject areas

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