Gastric lesions in transforming growth factor β-1 heterozygous mice

Gregory P. Boivin, Julian R. Molina, Ilona Ormsby, Grant Stemmermann, Thomas Doetschman

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Transforming growth factor β-1 (TGFβ1) is known to inhibit the growth of many epithelial cell types in culture. Consequently, it is important to determine whether it has any tumor suppressor activity in vitro. Fifteen heterozygous and eight wild type TGFβ1-deficient mice were examined to determine if there was a difference in lifespan or lesion development due to the loss of one TGFβ1 allele. Mice were killed when there was evidence of neoplasia or severe illness. There was no significant difference in the lifespan of the two groups. Hyperplastic lesions in the glandular mucosa were seen in 10 TGFβ1 (+/-) mice. These lesions were localized to the lesser curvature of the stomach, extending from the limiting ridge to the pylorus. Seven of the 10 glandular hyperplastic lesions in the TGFβ1 (+/-) mice had features similar to human gastritis cystica profunda. Associated with the glandular invasion of the muscularis were a mixed inflammatory infiltration of the surrounding muscular wall and mucosa with chronic vasculitis in the tissues adjacent to these lesions. In contrast to the distinct genotypic differences in lesion incidence observed in the glandular stomach, there was no significant difference in lesion incidence in other organs. The increased incidence of the hyperplastic lesions in the TGFβ1 (+/-) mice is highly suggestive that allelic loss of TGFβ1 plays an important role in the genesis of these lesions. However, allelic loss of TGFβ1 does not cause alterations in the incidence of neoplasia.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalLaboratory Investigation
Issue number2
StatePublished - Feb 1996

ASJC Scopus subject areas

  • General Medicine


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