G-quadruplex structures and G-quadruplex-interactive compounds.

Raveendra I. Mathad, Danzhou Yang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures. G-quadruplex-interactive compounds have been shown to inhibit telomerase access as well as telomere capping. Nuclear magnetic resonance (NMR) spectroscopy has been shown to be a powerful method in determining the G-quadruplex structures under physiologically relevant conditions. We present the NMR methodology used in our research group for structure determination of G-quadruplexes in solution and their interactions with small molecule compounds. An example of a G-quadruplex structure formed in the human telomere sequence recently solved in our laboratory is used as an example.

Original languageEnglish (US)
Pages (from-to)77-96
Number of pages20
JournalMethods in molecular biology (Clifton, N.J.)
StatePublished - 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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