Fédération Nationale Des Centres de Lutte Contre Le Cancer (FNCLCC) Grading, Margin Status and Tumor Location Associate With Survival Outcomes in Malignant Peripheral Nerve Sheath Tumors

Kristina M. Wakeman, Qian S. Zhang, Anshu Bandhlish, Lee D. Cranmer, Robert W. Ricciotti, Jose G. Mantilla

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Histologic grading using the Fédération Nationale des Centres de Lutte Contre Le Cancer (FNCLCC) system is not universally accepted as applicable to malignant peripheral nerve sheath tumor (MPNST), as its prognostic value is not well established. Methods: We retrospectively evaluated 99 cases of MPNST to investigate any association between the outcomes overall survival (OS) and progression-free survival (PFS), and predictor variables FNCLCC grade, clinical setting, tumor location, and tumor size at diagnosis using multivariable Cox proportional hazard analysis. Results: Univariable and multivariable analysis demonstrate a statistically significant association between FNCLCC grade and both OS and PFS when comparing tumors by histologic grade. Of note, no deaths were observed in patients with grade 1 MPNST. Other variables associated with unfavorable outcomes include fragmented resection and primary site, with tumors in the extremities having favorable OS, but not PFS, when compared with those in truncal locations. Tumors in the head and neck had favorable PFS, but not OS, compared with those in the trunk. No statistically significant differences in OS or PFS were observed when comparing patient age and sex, tumor size at diagnosis, clinical setting (primary vs. type-1 neurofibromatosis vs. radiation associated) or history of neoadjuvant therapy. Interobserver agreement for FNCLCC grading of these tumors was considered good (S* = 0.77, 95% confidence interval: 0.71-0.84). Conclusions: Association between FNCLCC grading and survival outcomes in MPNST suggests potential value to routinely grading these neoplasms. However, the subjectivity of the grading system, particularly when assigning a tumor differentiation score, may pose a challenge, especially in low and intermediate grade lesions.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2022
Externally publishedYes

Keywords

  • FNCLCC grading
  • Malignant peripheral nerve sheath tumor
  • Pathology
  • Sarcoma
  • Survival outcomes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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