Future of Sleep-Disordered Breathing Therapy Using a Mechanistic Approach

Rachel Jen, Michael A. Grandner, Atul Malhotra

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Sleep disordered breathing (SDB) is highly prevalent among patients with cardiovascular disease (CVD), and the relationship between SDB and CVD may be bidirectional. However, SDB remains underdiagnosed and undertreated. One of the major barriers identified by cardiologists is lack of satisfaction with SDB therapy. This situation could be the result of the discordance between treatment and the pathophysiological characteristics of SDB. This condition is caused by multiple pathophysiological mechanisms, which could be classified into upper airway anatomic compromise, pharyngeal dilator muscle dysfunction, and ventilatory control instability. However, the effective treatment of SDB remains limited, and positive airway pressure therapy is still the mainstay of the treatment. Therefore, we review the pathophysiological characteristics of SDB in this article, and we propose to provide individualized treatment of SDB based on the underlying mechanism. This approach requires further study but could potentially improve adherence and success of therapy.

Original languageEnglish (US)
Pages (from-to)880-888
Number of pages9
JournalCanadian Journal of Cardiology
Issue number7
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Future of Sleep-Disordered Breathing Therapy Using a Mechanistic Approach'. Together they form a unique fingerprint.

Cite this