Abstract
The entropy of fusion of 84 disubstituted benzenes was essentially constant and independent of the participation of the compounds in intramolecular or intermolecular hydrogen bonding. It was also independent of the shapes, sizes, and dipole moments of the rigid molecules studied. While the entropy of fusion was independent of these parameters, the melting point and the heat of fusion showed a direct dependence on molecular properties.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 565-568 |
| Number of pages | 4 |
| Journal | Journal of pharmaceutical sciences |
| Volume | 68 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1979 |
| Externally published | Yes |
Keywords
- Benzenes, disubstituted—entropy of fusion, melting point, heat of fusion, structure—activity relationships
- Entropy of fusion—disubstituted benzenes, independent of hydrogen bonding, shape, size, dipole moment of rigid molecules, structure‐activity relationships
- Melting point—analysis, disubstituted benzenes, structure‐activity relationships
ASJC Scopus subject areas
- Pharmaceutical Science