Further understanding the connection between Alzheimer's disease and Down syndrome

Heather M. Snyder; Lisa J. Bain; Adam M. Brickman; Maria C. Carrillo; Anna J. Esbensen; Joaquin M. Espinosa; Fabian Fernandez; Juan Fortea; Sigan L. Hartley; Elizabeth Head; James Hendrix; Priya S. Kishnani; Florence Lai; Patrick Lao; Cynthia Lemere; William Mobley; Elliott J. Mufson; Huntington Potter; Shahid H. Zaman; Ann Charlotte Granholm; H. Diana Rosas; Andre Strydom; Michelle Sie Whitten; Michael S. Rafii

doi:10.1002/alz.12112

Further understanding the connection between Alzheimer's disease and Down syndrome

Heather M. Snyder, Lisa J. Bain, Adam M. Brickman, Maria C. Carrillo, Anna J. Esbensen, Joaquin M. Espinosa, Fabian Fernandez, Juan Fortea, Sigan L. Hartley, Elizabeth Head, James Hendrix, Priya S. Kishnani, Florence Lai, Patrick Lao, Cynthia Lemere, William Mobley, Elliott J. Mufson, Huntington Potter, Shahid H. Zaman, Ann Charlotte GranholmH. Diana Rosas, Andre Strydom, Michelle Sie Whitten, Michael S. Rafii

Psychology

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). In March 2019, the Alzheimer's Association, Global Down Syndrome Foundation and the LuMind IDSC Foundation partnered to convene a workshop to explore the state of the research on the intersection of AD and DS research; to identify research gaps and unmet needs; and to consider how best to advance the field. This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus.

Original language	English (US)
Pages (from-to)	1065-1077
Number of pages	13
Journal	Alzheimer's and Dementia
Volume	16
Issue number	7
DOIs	https://doi.org/10.1002/alz.12112
State	Published - Jul 1 2020

Keywords

Alzheimer's disease
Down syndrome
trisomy
vascular contributions

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

Access to Document

10.1002/alz.12112

Cite this

Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., Hendrix, J., Kishnani, P. S., Lai, F., Lao, P., Lemere, C., Mobley, W., Mufson, E. J., Potter, H., Zaman, S. H., ... Rafii, M. S. (2020). Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimer's and Dementia, 16(7), 1065-1077. https://doi.org/10.1002/alz.12112

Snyder, HM, Bain, LJ, Brickman, AM, Carrillo, MC, Esbensen, AJ, Espinosa, JM, Fernandez, F, Fortea, J, Hartley, SL, Head, E, Hendrix, J, Kishnani, PS, Lai, F, Lao, P, Lemere, C, Mobley, W, Mufson, EJ, Potter, H, Zaman, SH, Granholm, AC, Rosas, HD, Strydom, A, Whitten, MS & Rafii, MS 2020, 'Further understanding the connection between Alzheimer's disease and Down syndrome', Alzheimer's and Dementia, vol. 16, no. 7, pp. 1065-1077. https://doi.org/10.1002/alz.12112

@article{4693169d9a84426d961787a48cd63c63,

title = "Further understanding the connection between Alzheimer's disease and Down syndrome",

abstract = "Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). In March 2019, the Alzheimer's Association, Global Down Syndrome Foundation and the LuMind IDSC Foundation partnered to convene a workshop to explore the state of the research on the intersection of AD and DS research; to identify research gaps and unmet needs; and to consider how best to advance the field. This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus.",

keywords = "Alzheimer's disease, Down syndrome, trisomy, vascular contributions",

author = "Snyder, {Heather M.} and Bain, {Lisa J.} and Brickman, {Adam M.} and Carrillo, {Maria C.} and Esbensen, {Anna J.} and Espinosa, {Joaquin M.} and Fabian Fernandez and Juan Fortea and Hartley, {Sigan L.} and Elizabeth Head and James Hendrix and Kishnani, {Priya S.} and Florence Lai and Patrick Lao and Cynthia Lemere and William Mobley and Mufson, {Elliott J.} and Huntington Potter and Zaman, {Shahid H.} and Granholm, {Ann Charlotte} and Rosas, {H. Diana} and Andre Strydom and Whitten, {Michelle Sie} and Rafii, {Michael S.}",

note = "Publisher Copyright: {\textcopyright} 2020 the Alzheimer's Association",

year = "2020",

month = jul,

day = "1",

doi = "10.1002/alz.12112",

language = "English (US)",

volume = "16",

pages = "1065--1077",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "7",

}

TY - JOUR

T1 - Further understanding the connection between Alzheimer's disease and Down syndrome

AU - Snyder, Heather M.

AU - Bain, Lisa J.

AU - Brickman, Adam M.

AU - Carrillo, Maria C.

AU - Esbensen, Anna J.

AU - Espinosa, Joaquin M.

AU - Fernandez, Fabian

AU - Fortea, Juan

AU - Hartley, Sigan L.

AU - Head, Elizabeth

AU - Hendrix, James

AU - Kishnani, Priya S.

AU - Lai, Florence

AU - Lao, Patrick

AU - Lemere, Cynthia

AU - Mobley, William

AU - Mufson, Elliott J.

AU - Potter, Huntington

AU - Zaman, Shahid H.

AU - Granholm, Ann Charlotte

AU - Rosas, H. Diana

AU - Strydom, Andre

AU - Whitten, Michelle Sie

AU - Rafii, Michael S.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). In March 2019, the Alzheimer's Association, Global Down Syndrome Foundation and the LuMind IDSC Foundation partnered to convene a workshop to explore the state of the research on the intersection of AD and DS research; to identify research gaps and unmet needs; and to consider how best to advance the field. This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus.

AB - Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). In March 2019, the Alzheimer's Association, Global Down Syndrome Foundation and the LuMind IDSC Foundation partnered to convene a workshop to explore the state of the research on the intersection of AD and DS research; to identify research gaps and unmet needs; and to consider how best to advance the field. This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus.

KW - Alzheimer's disease

KW - Down syndrome

KW - trisomy

KW - vascular contributions

UR - http://www.scopus.com/inward/record.url?scp=85087846527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85087846527&partnerID=8YFLogxK

U2 - 10.1002/alz.12112

DO - 10.1002/alz.12112

M3 - Review article

C2 - 32544310

AN - SCOPUS:85087846527

SN - 1552-5260

VL - 16

SP - 1065

EP - 1077

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 7

ER -

Further understanding the connection between Alzheimer's disease and Down syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this