Further understanding the connection between Alzheimer's disease and Down syndrome

Heather M. Snyder, Lisa J. Bain, Adam M. Brickman, Maria C. Carrillo, Anna J. Esbensen, Joaquin M. Espinosa, Fabian Fernandez, Juan Fortea, Sigan L. Hartley, Elizabeth Head, James Hendrix, Priya S. Kishnani, Florence Lai, Patrick Lao, Cynthia Lemere, William Mobley, Elliott J. Mufson, Huntington Potter, Shahid H. Zaman, Ann Charlotte GranholmH. Diana Rosas, Andre Strydom, Michelle Sie Whitten, Michael S. Rafii

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). In March 2019, the Alzheimer's Association, Global Down Syndrome Foundation and the LuMind IDSC Foundation partnered to convene a workshop to explore the state of the research on the intersection of AD and DS research; to identify research gaps and unmet needs; and to consider how best to advance the field. This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus.

Original languageEnglish (US)
Pages (from-to)1065-1077
Number of pages13
JournalAlzheimer's and Dementia
Issue number7
StatePublished - Jul 1 2020


  • Alzheimer's disease
  • Down syndrome
  • trisomy
  • vascular contributions

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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